HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PLCH1 (Q4KWH8)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)
Gene: PLCH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_12~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1693
+	Hs
		348700 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCH1_HUMAN (1-1693): 0: 2265: 100.00
+	Hs
		1070221 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PLCH1_HUMAN (1-1693): 0: 2265: 100.00
+	Hs
		895108 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PLCH1_HUMAN (1-1693): 0: 2265: 100.00
+	Hs
		349256 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCB3_HUMAN (6-1142): 0: 827: 22.41
+	Hs
		350087 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCB3_HUMAN (6-1142): 0: 827: 22.41
+	Hs
		349735 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCL2_HUMAN (2-1118): 0: 682: 21.59
+	Hs
		349202 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCD1_HUMAN (1-857): 0: 666: 28.06
+	Hs
		348580 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCD1_HUMAN (1-857): 0: 666: 28.06
+	Hs
		350690 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCL2_HUMAN (2-1118): 0: 682: 21.59
+	Hs
		349987 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCD1_HUMAN (1-857): 0: 666: 28.06
+	Hs
		349665 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		348942 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		349695 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCE1_HUMAN (235-916): 4.78e-178: 593: 27.97
+	Hs
		1070411 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		348976 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PLCE1_HUMAN (235-916): 4.78e-178: 593: 27.97
+	Hs
		350581 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		895288 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		914080 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PLCB4_HUMAN (20-1142): 0: 609: 17.90
+	Hs
		580971 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		253284 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PLCH2_HUMAN (1460-1666): 6.4e-61: 232: 31.13