Protein: MED6
Mediator of RNA polymerase II transcription subunit 6 (Activator-recruited cofactor 33 kDa component) (ARC33) (Mediator complex subunit 6) (hMed6) (Renal carcinoma antigen NY-REN-28)

Gene: MED6
Organism: Homo sapiens
Interactions: 94
UniProt ID: O75586

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001223 - transcription coactivator binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270486

CDK8
Cyclin-dependent kinase 8

16

4

Small-scale

0.985

High

270526

MED10
Mediator of RNA polymerase II transcription subunit 10

8

4

Small-scale

0.970

High

270528

CDK19
Cyclin-dependent kinase 19

6

4

High-throughput

0.947

High

270532

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

High-throughput

0.906

High

270534

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

Small-scale

0.895

High

270503

MED22
Mediator of RNA polymerase II transcription subunit 22

3

3

High-throughput

0.861

High

270480

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

High-throughput

0.789

High

270522

MED8
Mediator of RNA polymerase II transcription subunit 8

2

1

High-throughput

0.789

High

270537

MED29
Mediator of RNA polymerase II transcription subunit 29

6

2

Small-scale

0.736

High

270520

MED12
Mediator of RNA polymerase II transcription subunit 12

6

1

High-throughput

0.733

High

270529

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.732

High

270479

CCNC
Cyclin-C

6

2

Small-scale

0.729

High

48594

MED19
Mediator of RNA polymerase II transcription subunit 19

10

0

Small-scale

0.725

High

206596

MED7
Mediator of RNA polymerase II transcription subunit 7

5

4

High-throughput

0.722

High

270500

MED21
Mediator of RNA polymerase II transcription subunit 21

5

1

Small-scale

0.720

High

270527

MED18
Mediator of RNA polymerase II transcription subunit 18

5

2

Small-scale

0.718

High

270523

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

Small-scale

0.716

High

270504

MED1
Mediator of RNA polymerase II transcription subunit 1

7

0

Small-scale

0.714

High

270531

MED20
Mediator of RNA polymerase II transcription subunit 20

4

2

High-throughput

0.699

High

270540

MED23
Mediator of RNA polymerase II transcription subunit 23

4

1

Small-scale

0.691

High

270536

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.682

High

270514

MED25
Mediator of RNA polymerase II transcription subunit 25

4

1

Small-scale

0.672

High

270464

MED26
Mediator of RNA polymerase II transcription subunit 26

3

1

High-throughput

0.667

High

270510

MED27
Mediator of RNA polymerase II transcription subunit 27

3

1

Small-scale

0.662

High

270468

ESR1
Estrogen receptor

3

4

Small-scale

0.660

High

270478

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.656

High

270483

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.655

High

225320

MED14
Mediator of RNA polymerase II transcription subunit 14

3

5

Small-scale

0.650

High

270525

MED15
Mediator of RNA polymerase II transcription subunit 15

3

2

Small-scale

0.640

High

265284

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

270544

MED31
Mediator of RNA polymerase II transcription subunit 31

2

3

High-throughput

0.628

High

270476

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

High-throughput

0.611

High

270481

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

2

High-throughput

0.611

High

270538

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

270543

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

177635

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

181369

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

270477

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

270506

SMAD1
Mothers against decapentaplegic homolog 1

2

2

Small-scale

0.601

High

270539

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.601

High

270519

ESR2
Estrogen receptor beta

2

4

Small-scale

0.595

High

270492

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

270474

VDR
Vitamin D3 receptor

2

3

Small-scale

0.584

High

270521

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

73024

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

4

High-throughput

0.575

High

270469

PARP1
Poly [ADP-ribose] polymerase 1

2

0

Small-scale

0.569

High

270505

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.515

High

270466

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

270475

EGR1
Early growth response protein 1

1

0

High-throughput

0.513

High

270511

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

270533

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.513

High

270487

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

270488

SMCA4
Transcription activator BRG1

1

1

Small-scale

0.501

High

270545

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

Small-scale

0.501

High

270497

SRBP2
Sterol regulatory element-binding protein 2

1

1

Small-scale

0.500

High

270494

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.493

High

270501

CUL1
Cullin-1

1

0

Small-scale

0.493

High

270485

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.480

High

270502

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

243711

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

266287

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

270463

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

270465

EYA4
Eyes absent homolog 4

1

2

High-throughput

0.479

High

270471

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

270472

RARA
Retinoic acid receptor alpha

1

4

Small-scale

0.479

High

270473

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.479

High

270482

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

High-throughput

0.479

High

270489

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

270490

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.479

High

270496

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.479

High

270513

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

270515

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

1

High-throughput

0.479

High

270535

NLE1
Notchless protein homolog 1

1

2

High-throughput

0.479

High

270541

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.479

High

270542

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

270499

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.460

High

270462

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

270484

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

270491

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

270493

H4
Histone H4

1

0

High-throughput

0.458

High

270495

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

270498

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

270507

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

270512

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

270516

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

270517

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

270524

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

Small-scale

0.458

High

270530

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

91295

E5RFK5
Cyclin-C

1

2

High-throughput

0.445

High

270508

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

270518

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

270467

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

270509

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

270470

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024