HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30442766, 30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1332
+	Hs
		349478 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		348783 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		1070297 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		349719 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		348995 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		350664 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324710 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324709 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324808 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324711 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		349425 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		348748 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		1070265 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		350286 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		895142 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		349428 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		NRK_HUMAN (1-865): 2.05e-105: 369: 28.26
+	Hs
		348766 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		350320 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		1070479 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		350725 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60