HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 676
+	Hs
		349739 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		349013 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		349293 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		348648 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1035374 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		350144 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		350225 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		DOC11_HUMAN (2-457): 1.02e-111: 372: 16.08
+	Hs
		1070251 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		350257 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		349619 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		DOCK9_HUMAN (2-485): 1.15e-51: 196: 12.16
+	Hs
		1070378 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		DOCK9_HUMAN (2-485): 1.15e-51: 196: 12.16
+	Hs
		348931 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		1070403 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Hs
		349655 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		348930 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		349435 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		1070402 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PKHA5_HUMAN (6-453): 3.24e-26: 117: 15.35
+	Hs
		349438 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PHLB1_HUMAN (8-113): 8.34e-17: 87: 26.27
+	Hs
		350299 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PHLB2_HUMAN (9-114): 2.45e-24: 111: 28.04
+	Hs
		348756 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PHLB1_HUMAN (8-113): 8.34e-17: 87: 26.27