Interactor 1: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR
Interactor 2: PCSK9 (Q8NBP7)
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Gene: PCSK9
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.85 | 1.00 | 0.924 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23085658, 18753623, 18250299, 22081141, 25613181 |
| Identification Methods | affinity chromatography technology, anti bait coimmunoprecipitation, x-ray crystallography, filter binding, molecular sieving, surface plasmon resonance, blue native page |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FXa_inhibition~Peptidase_S8 |
| Common GO terms | GO:0001920 - negative regulation of receptor recycling GO:0005764 - lysosome GO:0005769 - early endosome GO:0005770 - late endosome GO:0005794 - Golgi apparatus and 8 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
