Protein: ECD
Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1)

Gene: ECD
Organism: Homo sapiens
Interactions: 150
UniProt ID: O95905

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351120

PRP8
Pre-mRNA-processing-splicing factor 8

9

1

Small-scale

0.755

High

351105

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

5

1

High-throughput

0.712

High

351150

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

4

3

High-throughput

0.694

High

351115

EAPP
E2F-associated phosphoprotein

5

0

High-throughput

0.682

High

351194

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

5

0

High-throughput

0.682

High

289394

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

3

1

High-throughput

0.667

High

351180

PIHD1
PIH1 domain-containing protein 1

2

1

Small-scale

0.662

High

351189

RUVB1
RuvB-like 1

2

1

Small-scale

0.654

High

351192

AAR2
Protein AAR2 homolog

5

1

High-throughput

0.652

High

351183

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.638

High

351182

NCDN
Neurochondrin

3

0

High-throughput

0.634

High

351184

ZNHI2
Zinc finger HIT domain-containing protein 2

4

1

High-throughput

0.633

High

351167

TXNIP
Thioredoxin-interacting protein

2

0

Small-scale

0.625

High

351072

MYH7
Myosin-7

2

0

High-throughput

0.602

High

351107

TEBP
Prostaglandin E synthase 3

2

0

High-throughput

0.602

High

351173

GPBL1
Vasculin-like protein 1

2

0

High-throughput

0.602

High

351090

GSK3B
Glycogen synthase kinase-3 beta

2

1

High-throughput

0.601

High

351138

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

351181

TLS1
Splicing factor C9orf78

2

0

High-throughput

0.585

High

351161

WDR83
WD repeat domain-containing protein 83

2

3

High-throughput

0.574

High

351081

CTNA1
Catenin alpha-1

2

0

Small-scale

0.559

High

227746

MYO1B
Unconventional myosin-Ib

1

2

High-throughput

0.536

High

351101

MYO9B
Unconventional myosin-IXb

1

2

High-throughput

0.536

High

351110

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

351135

SMYD4
Protein-lysine N-methyltransferase SMYD4

1

1

High-throughput

0.536

High

351159

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.536

High

351118

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

351086

PE2R3
Prostaglandin E2 receptor EP3 subtype

2

1

High-throughput

0.521

High

351099

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

351089

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.515

High

186356

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.513

High

351068

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.513

High

351083

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

351087

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

351091

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.513

High

351094

PCBP3
Poly(rC)-binding protein 3

1

0

High-throughput

0.513

High

351095

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

351096

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

351097

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

351112

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

351133

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

351145

MED12
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.513

High

351146

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

351163

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

351166

RBM38
RNA-binding protein 38

1

0

High-throughput

0.513

High

351174

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

351070

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

351098

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.501

High

351084

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

172382

XPO1
Exportin-1

1

2

High-throughput

0.479

High

335756

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

1

High-throughput

0.479

High

351075

GCFC2
Intron Large complex component GCFC2

1

1

High-throughput

0.479

High

351092

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

Small-scale

0.479

High

351117

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

351137

AHI1
Jouberin

1

5

High-throughput

0.479

High

351140

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.479

High

351153

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

1

High-throughput

0.479

High

351155

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.479

High

351157

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

351162

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

351185

XPO7
Exportin-7

1

2

High-throughput

0.479

High

351186

HOOK1
Protein Hook homolog 1

1

1

High-throughput

0.479

High

351188

PRP19
Pre-mRNA-processing factor 19

1

2

High-throughput

0.479

High

351064

GCR
Glucocorticoid receptor

1

0

Small-scale

0.460

High

184258

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

240408

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

247201

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

292999

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

316713

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

339915

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.458

High

351062

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

351065

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

351066

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.458

High

351067

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

351069

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

351071

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

351074

EZRI
Ezrin

1

0

High-throughput

0.458

High

351077

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

351082

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

0

High-throughput

0.458

High

351102

CUL3
Cullin-3

1

0

High-throughput

0.458

High

351103

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

351104

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

351108

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.458

High

351109

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.458

High

351113

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

351125

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

351128

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

351130

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

351144

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

351148

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.458

High

351151

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

0

Small-scale

0.458

High

351154

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

351158

NECD
Necdin

1

0

High-throughput

0.458

High

351164

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

351170

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

351171

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

351175

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

351176

ANLN
Anillin

1

0

High-throughput

0.458

High

351178

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.458

High

163885

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.445

High

171383

S27A2
Long-chain fatty acid transport protein 2

1

3

High-throughput

0.445

High

351063

S1PR4
Sphingosine 1-phosphate receptor 4

1

2

High-throughput

0.445

High

351076

S1PR1
Sphingosine 1-phosphate receptor 1

1

2

High-throughput

0.445

High

351093

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

351127

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.445

High

351131

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

1

High-throughput

0.445

High

351132

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

1

High-throughput

0.445

High

351136

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.445

High

351160

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

High-throughput

0.445

High

351169

RPAP3
RNA polymerase II-associated protein 3

1

2

Small-scale

0.445

High

351193

MYO5A
Unconventional myosin-Va

1

2

High-throughput

0.445

High

351177

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

351126

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

351152

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.437

High

351156

DAA10
Dynein axonemal assembly factor 10

1

1

High-throughput

0.437

High

351168

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

273325

NPHP4
Nephrocystin-4

1

0

High-throughput

0.426

High

351079

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

0

High-throughput

0.426

High

351080

SSR2
Somatostatin receptor type 2

1

0

High-throughput

0.426

High

351141

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.426

High

351149

HDA11
Histone deacetylase 11

1

0

High-throughput

0.426

High

351165

TKTL2
Transketolase-like protein 2

1

0

High-throughput

0.426

High

351187

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

351190

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.426

High

351078

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.407

High

351116

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

351119

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.407

High

351122

S27A1
Long-chain fatty acid transport protein 1

1

3

High-throughput

0.407

High

351191

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.407

High

351142

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

351147

K1143
Uncharacterized protein KIAA1143

2

0

High-throughput

0.328

High

351121

TTC27
Tetratricopeptide repeat protein 27

2

0

High-throughput

0.318

High

351143

LIPH
Lipase member H

2

0

High-throughput

0.318

High

351085

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.279

Low

351106

PDK3
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

351123

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

351088

PSN2
Presenilin-2

1

0

High-throughput

0.251

Low

351073

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

351179

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

50078

S22AN
Solute carrier family 22 member 23

1

0

High-throughput

0.232

Low

337658

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.232

Low

351100

PLD1
Phospholipase D1

1

0

High-throughput

0.232

Low

351111

CD226
CD226 antigen

1

0

High-throughput

0.232

Low

351114

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

351124

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.232

Low

351129

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

351134

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.232

Low

351139

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.232

Low

351172

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025