HitPredict - High confidence protein-protein interactions

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: TSP1 (P07996)
Thrombospondin-1 (Glycoprotein G)
Gene: THBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	1550960, 15864306
Identification Methods	biochemical, solid phase assay
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002040 - sprouting angiogenesis GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008284 - positive regulation of cell population proliferation GO:0008285 - negative regulation of cell population proliferation and 15 others more... GO:0009410 - response to xenobiotic stimulus GO:0009986 - cell surface GO:0010763 - positive regulation of fibroblast migration GO:0030335 - positive regulation of cell migration GO:0031012 - extracellular matrix GO:0031093 - platelet alpha granule lumen GO:0032570 - response to progesterone GO:0032760 - positive regulation of tumor necrosis factor production GO:0043536 - positive regulation of blood vessel endothelial cell migration GO:0043537 - negative regulation of blood vessel endothelial cell migration GO:0048661 - positive regulation of smooth muscle cell proliferation GO:0050921 - positive regulation of chemotaxis GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0062023 - collagen-containing extracellular matrix GO:2000353 - positive regulation of endothelial cell apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	390
Hs

1	1170

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024