Protein: HMGA2
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)

Gene: HMGA2
Organism: Homo sapiens
Interactions: 121
UniProt ID: P52926

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000228 - nuclear chromosome
GO:0000976 - transcription cis-regulatory region binding
GO:0001837 - epithelial to mesenchymal transition
GO:0002062 - chondrocyte differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523619

XRCC6
X-ray repair cross-complementing protein 6

3

2

Small-scale

0.671

High

265973

PSIP1
PC4 and SFRS1-interacting protein

2

2

Small-scale

0.611

High

455252

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.611

High

559028

H15
Histone H1.5

2

7

High-throughput

0.601

High

857451

H31
Histone H3.1

2

2

High-throughput

0.584

High

414221

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

418070

NPM
Nucleophosmin

2

0

Small-scale

0.577

High

857495

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.561

High

857501

ANM6
Protein arginine N-methyltransferase 6

1

1

Small-scale

0.561

High

346300

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

857481

E4F1
Transcription factor E4F1

1

0

Small-scale

0.554

High

386362

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

857453

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

235766

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

Small-scale

0.536

High

587479

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.536

High

134859

IMA3
Importin subunit alpha-3

1

1

High-throughput

0.536

High

317938

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

2

High-throughput

0.536

High

556823

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

586632

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

857450

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

857476

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.536

High

857492

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.536

High

857496

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.536

High

857515

PARP2
Poly [ADP-ribose] polymerase 2

1

3

High-throughput

0.536

High

857518

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.536

High

857520

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.529

High

857486

SYDE1
Rho GTPase-activating protein SYDE1

2

1

High-throughput

0.521

High

508884

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.515

High

857448

H4
Histone H4

1

1

Small-scale

0.515

High

857469

NUMA1
Nuclear mitotic apparatus protein 1

1

2

Small-scale

0.515

High

857512

DUX4
Double homeobox protein 4

1

1

High-throughput

0.515

High

857517

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.513

High

125867

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

739041

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

836695

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

857455

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

857458

SP2
Transcription factor Sp2

1

0

High-throughput

0.513

High

857460

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

857462

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

0

High-throughput

0.513

High

857465

TOP3A
DNA topoisomerase 3-alpha

1

0

High-throughput

0.513

High

857494

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.513

High

652793

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.501

High

857459

TF65
Transcription factor p65

1

2

Small-scale

0.501

High

857472

PCBP2
Poly(rC)-binding protein 2

1

1

Small-scale

0.501

High

338170

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.500

High

600538

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.500

High

857471

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

566335

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

643458

PTBP1
Polypyrimidine tract-binding protein 1

1

0

Small-scale

0.480

High

713773

RYK
Tyrosine-protein kinase RYK

1

0

High-throughput

0.479

High

128082

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

168756

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

171376

SMAD9
Mothers against decapentaplegic homolog 9

1

3

Small-scale

0.479

High

260809

H2AY
Core histone macro-H2A.1

1

7

Small-scale

0.479

High

449617

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

488956

H14
Histone H1.4

1

7

Small-scale

0.479

High

503735

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

524849

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

559615

H12
Histone H1.2

1

7

Small-scale

0.479

High

595160

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

631381

BRD2
Bromodomain-containing protein 2

1

4

Small-scale

0.479

High

643276

HMGB2
High mobility group protein B2

1

4

Small-scale

0.479

High

785782

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

Small-scale

0.479

High

801039

KI67
Proliferation marker protein Ki-67

1

4

Small-scale

0.479

High

850873

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.479

High

857449

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

857454

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.479

High

857461

SSRP1
FACT complex subunit SSRP1

1

4

Small-scale

0.479

High

857463

CBX3
Chromobox protein homolog 3

1

3

Small-scale

0.479

High

857467

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

1

Small-scale

0.479

High

857468

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

Small-scale

0.479

High

857473

SMAD1
Mothers against decapentaplegic homolog 1

1

3

Small-scale

0.479

High

857475

B2LA1
Bcl-2-related protein A1

1

1

Small-scale

0.479

High

857487

H32
Histone H3.2

1

2

Small-scale

0.479

High

857488

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.479

High

857493

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

857497

H2A1C
Histone H2A type 1-C

1

5

Small-scale

0.479

High

857498

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.479

High

857499

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

Small-scale

0.479

High

857502

SMAD5
Mothers against decapentaplegic homolog 5

1

3

Small-scale

0.479

High

857503

H2A1J
Histone H2A type 1-J

1

5

Small-scale

0.479

High

857504

H2B1L
Histone H2B type 1-L

1

2

Small-scale

0.479

High

857505

VRK1
Serine/threonine-protein kinase VRK1

1

3

High-throughput

0.479

High

857508

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.479

High

857509

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

857514

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.479

High

857519

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

158763

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

161804

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

321735

WIZ
Protein Wiz

1

0

Small-scale

0.458

High

563579

ZNF24
Zinc finger protein 24

1

0

Small-scale

0.458

High

564842

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

857452

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

857456

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

857470

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

857474

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

857477

BOREA
Borealin

1

0

Small-scale

0.458

High

857478

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

Small-scale

0.458

High

857482

CDCA2
Cell division cycle-associated protein 2

1

0

Small-scale

0.458

High

857490

POGZ
Pogo transposable element with ZNF domain

1

0

Small-scale

0.458

High

857500

Z512B
Zinc finger protein 512B

1

0

Small-scale

0.458

High

857506

PCGF1
Polycomb group RING finger protein 1

1

0

High-throughput

0.458

High

857510

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

Small-scale

0.458

High

857513

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

857516

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.458

High

665182

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.457

High

496618

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

555367

H2AX
Histone H2AX

1

7

High-throughput

0.445

High

857464

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.445

High

857480

H37
Histone H3-7

1

2

High-throughput

0.445

High

857483

DUX4C
Double homeobox protein 4C

1

1

High-throughput

0.445

High

857479

RHG21
Rho GTPase-activating protein 21

1

1

High-throughput

0.437

High

857484

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

857489

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.279

Low

857511

RBP17
Ran-binding protein 17

1

0

High-throughput

0.279

Low

857457

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

0

High-throughput

0.261

Low

255613

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

857466

CD166
CD166 antigen

1

0

High-throughput

0.249

Low

857485

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

857491

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

857507

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024