HitPredict

Interactor 1: PTHY (P01270)
Parathyroid hormone (PTH) (Parathormone) (Parathyrin)
Gene: PTH

Interactor 2: PTH1R (Q03431)
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
Gene: PTH1R

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.828

The method score is based on:

Property Details
Experiments 9108031, 19674967
Identification Methods pull down, x-ray crystallography, bio-layer interferometry, amplified luminescent proximity homogeneous assay
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_2~Parathyroid, HRM~Parathyroid
Common GO terms GO:0001501 - skeletal system development
GO:0006874 - intracellular calcium ion homeostasis
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0030282 - bone mineralization
and 2 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 115
Hs

1 593
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024