Protein: LGI1
Leucine-rich glioma-inactivated protein 1 (Epitempin-1)

Gene: LGI1
Organism: Homo sapiens
Interactions: 52
UniProt ID: O95970

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351807

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

2

2

Small-scale

0.705

High

171650

GAK
Cyclin-G-associated kinase

1

3

High-throughput

0.691

High

337241

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

4

High-throughput

0.691

High

343541

OXSR1
Serine/threonine-protein kinase OSR1

1

4

High-throughput

0.691

High

351782

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

2

High-throughput

0.691

High

351798

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

15

High-throughput

0.691

High

351808

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

6

High-throughput

0.691

High

274848

LRP5
Low-density lipoprotein receptor-related protein 5

1

4

High-throughput

0.536

High

351780

MARE2
Microtubule-associated protein RP/EB family member 2

1

1

High-throughput

0.536

High

351785

ARSK
Arylsulfatase K

1

4

High-throughput

0.536

High

351791

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.536

High

351794

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.536

High

351796

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

1

High-throughput

0.536

High

351800

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

High-throughput

0.536

High

351795

CLIC6
Chloride intracellular channel protein 6

1

0

High-throughput

0.518

High

161690

APAF
Apoptotic protease-activating factor 1

1

0

High-throughput

0.513

High

351770

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

351773

HSP7E
Heat shock 70 kDa protein 14

1

0

High-throughput

0.513

High

351774

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

351777

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.513

High

351783

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

0

High-throughput

0.513

High

351787

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.513

High

351788

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.513

High

351789

P3H3
Prolyl 3-hydroxylase 3

1

0

High-throughput

0.513

High

351790

BANP
Protein BANP

1

0

High-throughput

0.513

High

351792

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

0

High-throughput

0.513

High

351797

METH
Methionine synthase

1

0

High-throughput

0.513

High

351801

TOR3A
Torsin-3A

1

0

High-throughput

0.513

High

351810

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

298563

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.489

High

321398

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.489

High

351776

SKP2
S-phase kinase-associated protein 2

1

20

High-throughput

0.489

High

351778

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

High-throughput

0.489

High

351781

ELF2
ETS-related transcription factor Elf-2

1

1

High-throughput

0.489

High

351786

STXB4
Syntaxin-binding protein 4

1

5

High-throughput

0.489

High

351793

CTF18
Chromosome transmission fidelity protein 18 homolog

1

1

High-throughput

0.489

High

351803

CHSTC
Carbohydrate sulfotransferase 12

1

2

High-throughput

0.489

High

351806

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

7

High-throughput

0.489

High

351809

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

351772

DLG4
Disks large homolog 4

1

12

Small-scale

0.479

High

105041

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

351771

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

249942

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.279

Low

326640

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

351769

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

351775

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.279

Low

351779

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.279

Low

351784

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

0

High-throughput

0.279

Low

351799

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.279

Low

351802

ARP8
Actin-related protein 8

1

0

High-throughput

0.279

Low

351804

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

351805

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025