HitPredict

Interactor 1: IGF2 (P01344)
Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]
Gene: IGF2

Interactor 2: IBP3 (P17936)
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
Gene: IGFBP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	11749962, 9497324, 11600567, 9446566, 22578544
Identification Methods	pull down, bio-layer interferometry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IGFBP~Insulin, Insulin~Thyroglobulin_1
Common GO terms	GO:0001649 - osteoblast differentiation GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 180 Hs			1 291
+	Hs
		352350 IGF2_HUMAN (1-180): 1.87e-107: 306: 100.00		IBP5_HUMAN (32-286): 5.42e-68: 214: 44.11
+	Hs
		352348 IGF2_HUMAN (1-180): 1.87e-107: 306: 100.00		IBP4_HUMAN (38-288): 1.64e-59: 192: 33.98
+	Hs
		352343 IGF2_HUMAN (1-180): 1.87e-107: 306: 100.00		IBP1_HUMAN (33-286): 3.88e-59: 191: 29.62
+	Hs
		352347 IGF2_HUMAN (1-180): 1.87e-107: 306: 100.00		IBP2_HUMAN (37-286): 1.1e-57: 189: 31.90
+	Hs
		352349 IGF2_HUMAN (1-180): 1.87e-107: 306: 100.00		IBP6_HUMAN (33-275): 3.13e-39: 139: 31.43
+	Hs
		392950 IGF1_HUMAN (13-131): 9.24e-48: 155: 47.20		IBP3_HUMAN (1-291): 2.45e-87: 264: 100.00
+	Hs
		392953 IGF1_HUMAN (13-131): 9.24e-48: 155: 47.20		IBP5_HUMAN (32-286): 5.42e-68: 214: 44.11
+	Hs
		392952 IGF1_HUMAN (13-131): 9.24e-48: 155: 47.20		IBP4_HUMAN (38-288): 1.64e-59: 192: 33.98
+	Hs
		392948 IGF1_HUMAN (13-131): 9.24e-48: 155: 47.20		IBP1_HUMAN (33-286): 3.88e-59: 191: 29.62
+	Hs
		392951 IGF1_HUMAN (13-131): 9.24e-48: 155: 47.20		IBP2_HUMAN (37-286): 1.1e-57: 189: 31.90