Protein: TOP3A
DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)

Gene: TOP3A
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q13472

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003677 - DNA binding
GO:0003697 - single-stranded DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926347

BLM
RecQ-like DNA helicase BLM

13

11

Small-scale

0.983

High

1106459

RMI1
RecQ-mediated genome instability protein 1

10

5

Small-scale

0.975

High

1106438

FANCM
Fanconi anemia group M protein

3

6

Small-scale

0.857

High

1106456

TDRD3
Tudor domain-containing protein 3

1

4

Small-scale

0.710

High

1106442

RMI2
RecQ-mediated genome instability protein 2

5

0

Small-scale

0.687

High

187511

FANCA
Fanconi anemia group A protein

5

0

Small-scale

0.676

High

1106436

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

3

1

High-throughput

0.667

High

588626

RFA2
Replication protein A 32 kDa subunit

3

1

Small-scale

0.656

High

695383

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

1

Small-scale

0.656

High

1106423

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

904679

MECP2
Methyl-CpG-binding protein 2

2

1

High-throughput

0.628

High

1106432

RM21
Large ribosomal subunit protein bL21m

2

1

High-throughput

0.628

High

316287

RECQ5
ATP-dependent DNA helicase Q5

1

10

Small-scale

0.618

High

768118

RFA3
Replication protein A 14 kDa subunit

2

1

Small-scale

0.611

High

892560

DNLI3
DNA ligase 3

2

1

High-throughput

0.611

High

349667

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

572357

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

2

0

High-throughput

0.602

High

641771

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

716677

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.602

High

946485

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1106425

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

1106435

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

1106446

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.602

High

1106450

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

552956

PIP
Prolactin-inducible protein

2

1

High-throughput

0.601

High

65975

CCD69
Coiled-coil domain-containing protein 69

2

0

High-throughput

0.585

High

654108

XPA
DNA repair protein complementing XP-A cells

2

0

High-throughput

0.576

High

1106422

ERC6L
DNA excision repair protein ERCC-6-like

1

2

High-throughput

0.575

High

413775

P53
Cellular tumor antigen p53

2

3

Small-scale

0.571

High

919936

PLK1
Serine/threonine-protein kinase PLK1

2

2

High-throughput

0.571

High

1106426

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

1106439

CENPS
Centromere protein S

2

0

Small-scale

0.559

High

1106445

TSNAX
Translin-associated protein X

1

1

Small-scale

0.552

High

1106420

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1106447

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

2

High-throughput

0.536

High

1106449

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.536

High

1106415

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.530

High

528446

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

869155

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

915441

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

940004

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.513

High

1106419

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1106427

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.513

High

1106443

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1106451

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.513

High

1106454

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1106461

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.513

High

1106462

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

1106418

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.493

High

1106428

RIF1
Telomere-associated protein RIF1

1

1

Small-scale

0.484

High

471013

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

487274

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

629840

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

799079

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

856260

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

1048497

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

1099852

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1106413

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1106424

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1106431

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1106433

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1106437

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

Small-scale

0.479

High

1106452

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

185192

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.458

High

238509

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

287290

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.458

High

342856

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

349986

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

411880

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

606729

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

851886

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

979609

H4
Histone H4

1

0

High-throughput

0.458

High

1081732

FP100
Fanconi anemia core complex-associated protein 100

1

0

Small-scale

0.458

High

1106414

COTL1
Coactosin-like protein

1

0

High-throughput

0.458

High

1106429

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1106430

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1106440

HROB
Homologous recombination OB-fold protein

1

0

Small-scale

0.458

High

1106455

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

1106457

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1106460

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

529749

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1106453

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

653299

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1106434

SHLD2
Shieldin complex subunit 2

1

0

Small-scale

0.426

High

878314

MRP
MARCKS-related protein

2

0

High-throughput

0.328

High

1106421

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.328

High

1106444

MET2A
tRNA N(3)-cytidine methyltransferase METTL2A

2

0

High-throughput

0.328

High

194418

GR6
Protein GR6

1

0

High-throughput

0.279

Low

1106416

MAP7
Ensconsin

1

0

High-throughput

0.279

Low

1106417

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.279

Low

1106441

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.279

Low

1106448

TMM79
Transmembrane protein 79

1

0

Small-scale

0.249

Low

1106458

Q9H8E5
cDNA FLJ13705 fis, clone PLACE2000302

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025