HitPredict

Interactor 1: TNFB (P01374)
Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)
Gene: LTA

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 8387891, 8288897, 1310388, 8182064, 2170974, 8171323
Identification Methods x-ray crystallography, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0005615 - extracellular space
GO:0005886 - plasma membrane
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 205
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024