HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: S10AB (P31949)
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
Gene: S100A11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.566

Property	Details
Experiments	36555597
Identification Methods	pull down, classical fluorescence spectroscopy, surface plasmon resonance, cross-linking study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 105
+	Hs
		352545 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		352500 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		352578 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AC_HUMAN (8-98): 8.18e-32: 108: 36.26
+	Hs
		352442 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10A6_HUMAN (9-95): 2.4e-27: 97.3: 32.18
+	Hs
		352693 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		S10AD_HUMAN (8-89): 2.97e-24: 90: 39.02