HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TNF~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 1948
+	Hs
		352674 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		NEO1_HUMAN (322-1447): 6.5e-95: 341: 13.80
+	Hs
		352494 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		PTPRZ_HUMAN (1387-1668): 4.97e-47: 189: 27.21