Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)

Gene: TOP1, topA
Organism: Escherichia coli K-12
Interactions: 70
UniProt ID: P06612

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003916 - DNA topoisomerase activity
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005694 - chromosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444300

TOP3
DNA topoisomerase 3

2

1

High-throughput

0.789

High

444302

RECQ
ATP-dependent DNA helicase RecQ

2

10

High-throughput

0.789

High

444305

SRMB
ATP-dependent RNA helicase SrmB

2

2

High-throughput

0.789

High

444269

RL19
Large ribosomal subunit protein bL19

2

1

High-throughput

0.612

High

444267

SYL
Leucine--tRNA ligase

2

2

High-throughput

0.608

High

444271

RL33
Large ribosomal subunit protein bL33

2

1

High-throughput

0.588

High

444272

RS10
Small ribosomal subunit protein uS10

2

1

High-throughput

0.588

High

444290

RL13
Large ribosomal subunit protein uL13

2

2

High-throughput

0.588

High

444273

RS13
Small ribosomal subunit protein uS13

2

0

High-throughput

0.585

High

361733

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.585

High

444317

RLUB
Ribosomal large subunit pseudouridine synthase B

2

0

High-throughput

0.585

High

444279

RPOZ
DNA-directed RNA polymerase subunit omega

2

0

High-throughput

0.563

High

444283

RPOB
DNA-directed RNA polymerase subunit beta

2

0

High-throughput

0.563

High

444321

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.563

High

444313

HOLC
DNA polymerase III subunit chi

1

1

High-throughput

0.561

High

444306

RECJ
Single-stranded-DNA-specific exonuclease RecJ

2

1

High-throughput

0.558

High

444277

RNH
Ribonuclease HI

2

1

High-throughput

0.537

High

368818

SYA
Alanine--tRNA ligase

1

2

High-throughput

0.536

High

382616

RS7
Small ribosomal subunit protein uS7

1

1

High-throughput

0.536

High

444276

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

444286

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.536

High

444289

CSPC
Cold shock-like protein CspC

1

1

High-throughput

0.536

High

444315

RSMB
Ribosomal RNA small subunit methyltransferase B

1

1

High-throughput

0.536

High

444322

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.536

High

444301

DNLJ
DNA ligase

1

0

High-throughput

0.518

High

444268

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.513

High

444281

TRPB
Tryptophan synthase beta chain

1

0

High-throughput

0.513

High

444284

YCIA
Acyl-CoA thioester hydrolase YciA

1

0

High-throughput

0.513

High

444285

RIMJ
[Ribosomal protein uS5]-alanine N-acetyltransferase

1

0

High-throughput

0.513

High

444287

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

0

High-throughput

0.513

High

444303

PRLF
Antitoxin PrlF

1

0

High-throughput

0.513

High

444307

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.513

High

444311

GLND
Bifunctional uridylyltransferase/uridylyl-removing enzyme

1

0

High-throughput

0.513

High

444316

KDGK
2-dehydro-3-deoxygluconokinase

1

0

High-throughput

0.513

High

444318

IADA
Isoaspartyl dipeptidase

1

0

High-throughput

0.513

High

444319

RSTA
Transcriptional regulatory protein RstA

1

0

High-throughput

0.513

High

444266

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

3

High-throughput

0.489

High

444288

YBIT
Probable ATP-binding protein YbiT

1

1

High-throughput

0.489

High

444329

HSCC
Chaperone protein HscC

1

3

High-throughput

0.489

High

444270

RL28
Large ribosomal subunit protein bL28

1

1

High-throughput

0.484

High

444275

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.484

High

444294

DBHA
DNA-binding protein HU-alpha

1

2

High-throughput

0.484

High

444295

DBHB
DNA-binding protein HU-beta

1

2

High-throughput

0.484

High

444323

RL22
Large ribosomal subunit protein uL22

1

1

High-throughput

0.484

High

444274

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.464

High

444278

RPOA
DNA-directed RNA polymerase subunit alpha

1

0

High-throughput

0.464

High

444282

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

444293

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

444296

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.464

High

444297

ROB
Right origin-binding protein

1

0

High-throughput

0.464

High

444327

KDGR
HTH-type transcriptional regulator KdgR

1

0

High-throughput

0.458

High

444299

SSB
Single-stranded DNA-binding protein

1

3

High-throughput

0.445

High

444291

ARTP
Arginine transport ATP-binding protein ArtP

1

2

High-throughput

0.442

High

444298

RPOE
ECF RNA polymerase sigma-E factor

1

0

High-throughput

0.438

High

444314

FLIH
Flagellar assembly protein FliH

1

0

High-throughput

0.438

High

444292

ATPA
ATP synthase subunit alpha

1

1

High-throughput

0.437

High

444280

TIG
Trigger factor

1

0

Small-scale

0.426

High

444320

NIFJ
Probable pyruvate-flavodoxin oxidoreductase

1

1

High-throughput

0.417

High

444304

HYAD
Hydrogenase 1 maturation protease

2

0

High-throughput

0.330

High

444312

YIGZ
IMPACT family member YigZ

2

0

High-throughput

0.318

High

393939

RBSB
Ribose import binding protein RbsB

1

0

High-throughput

0.282

High

444324

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.282

High

444308

LPXM
Lipid A biosynthesis myristoyltransferase

1

0

High-throughput

0.279

Low

444309

GABP
Gamma-aminobutyric acid permease

1

0

High-throughput

0.279

Low

444310

WAAL
O-antigen ligase

1

0

High-throughput

0.279

Low

444325

MACA
Macrolide export protein MacA

1

0

High-throughput

0.279

Low

444328

FETA
Probable iron export ATP-binding protein FetA

1

0

High-throughput

0.279

Low

444330

RSXC
Ion-translocating oxidoreductase complex subunit C

1

0

High-throughput

0.279

Low

444331

YBER
Uncharacterized protein YbeR

1

0

High-throughput

0.279

Low

444326

FLGA
Flagella basal body P-ring formation protein FlgA

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025