HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18713975
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0140374 - antiviral innate immune response GO:1900017 - positive regulation of cytokine production involved in inflammatory response
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 427
+	Hs
		841072 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Mm
		420389 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Hs
		841070 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		352458 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Mm
		420386 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		IRF1_MOUSE (1-158): 5.26e-49: 171: 26.99
+	Hs
		501016 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		536494 TNF10_HUMAN (53-233): 1.94e-46: 157: 19.72		IRF2_HUMAN (1-116): 1.85e-48: 170: 33.90