HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	30561431, 27307491, 27545878, 20005846
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0045071 - negative regulation of viral genome replication GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050729 - positive regulation of inflammatory response GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 636
+	Mm
		420411 TNFA_MOUSE (1-233): 1.68e-95: 280: 78.81		TNIP1_MOUSE (1-636): 1.34e-64: 226: 82.28
+	Hs
		352687 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		TNIP3_HUMAN (276-538): 4.86e-22: 99.3: 36.67
+	Hs
		352510 TNFA_HUMAN (1-233): 1.87e-111: 320: 100.00		MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33