HitPredict

Interactor 1: IFNB (P01574)
Interferon beta (IFN-beta) (Fibroblast interferon)
Gene: IFNB1

Interactor 2: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	28514442, 33961781, 10049744, 7592797
Identification Methods	affinity chromatography technology, coimmunoprecipitation, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Interfer-bind~Interferon, Interferon~Tissue_fac
Common GO terms	GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0009615 - response to virus GO:0035458 - cellular response to interferon-beta GO:0060337 - type I interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 187 Hs			1 557
+	Hs
		352767 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00
+	Hs
		566005 IFNA8_HUMAN (9-187): 2.29e-67: 205: 29.95		INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00
+	Hs
		352874 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57
+	Hs
		352827 IFNA5_HUMAN (9-186): 8.62e-76: 226: 31.18		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57
+	Hs
		352750 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57
+	Hs
		352768 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57
+	Hs
		699608 IFNA8_HUMAN (9-187): 2.29e-67: 205: 29.95		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57
+	Hs
		392909 IFNW1_HUMAN (16-187): 1.41e-61: 191: 31.82		INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57