HitPredict

Interactor 1: IFNB (P01574)
Interferon beta (IFN-beta) (Fibroblast interferon)
Gene: IFNB1

Interactor 2: IRF7 (Q92985)
Interferon regulatory factor 7 (IRF-7)
Gene: IRF7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	15664995, 10938111, 16014923, 14729983, 19349300
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility shift assay, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009615 - response to virus GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 187 Hs			1 503
+	Hs
		352758 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF7_HUMAN (1-503): 0: 530: 100.00
+	Hs
		352775 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF7_HUMAN (1-503): 0: 530: 100.00
+	Hs
		352791 IFNA7_HUMAN (9-186): 3.79e-72: 218: 32.62		IRF7_HUMAN (1-503): 0: 530: 100.00
+	Hs
		352848 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF7_HUMAN (1-503): 0: 530: 100.00
+	Hs
		352882 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF5_HUMAN (7-501): 7.62e-144: 423: 26.68
+	Hs
		352753 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF5_HUMAN (7-501): 7.62e-144: 423: 26.68
+	Hs
		352842 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF5_HUMAN (7-501): 7.62e-144: 423: 26.68
+	Mm
		352891 IFNB_MOUSE (1-187): 4.49e-60: 186: 49.20		IRF5_MOUSE (8-501): 9.34e-142: 418: 26.34
+	Hs
		352878 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF8_HUMAN (12-485): 3.83e-123: 368: 21.04
+	Mm
		352888 IFNB_MOUSE (1-187): 4.49e-60: 186: 49.20		IRF8_MOUSE (12-485): 9.06e-127: 377: 21.88
+	Hs
		352862 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF2_HUMAN (8-343): 2.54e-87: 274: 17.54
+	Hs
		352861 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF1_HUMAN (8-276): 4.24e-71: 230: 19.00
+	Hs
		352745 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF1_HUMAN (8-276): 4.24e-71: 230: 19.00
+	Hs
		352766 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF1_HUMAN (8-276): 4.24e-71: 230: 19.00
+	Hs
		352837 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF1_HUMAN (8-276): 4.24e-71: 230: 19.00
+	Hs
		352883 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF3_HUMAN (6-263): 1.1e-60: 207: 25.66
+	Hs
		352755 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF3_HUMAN (6-263): 1.1e-60: 207: 25.66
+	Hs
		352770 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF3_HUMAN (6-263): 1.1e-60: 207: 25.66
+	Hs
		352788 IFNA7_HUMAN (9-186): 3.79e-72: 218: 32.62		IRF3_HUMAN (6-263): 1.1e-60: 207: 25.66
+	Hs
		352844 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF3_HUMAN (6-263): 1.1e-60: 207: 25.66