Protein: TXND5
Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)

Gene: TXND5, TXNDC5
Organism: Homo sapiens
Interactions: 171
UniProt ID: Q8NBS9

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005576 - extracellular region
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1097005

PRDX4
Peroxiredoxin-4

2

14

Small-scale

0.737

High

732359

PRDX2
Peroxiredoxin-2

1

14

Small-scale

0.724

High

1334128

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

9

Small-scale

0.724

High

566761

PDIA4
Protein disulfide-isomerase A4

1

15

High-throughput

0.618

High

666111

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

1

High-throughput

0.618

High

1098445

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.618

High

1312014

DJC10
DnaJ homolog subfamily C member 10

1

18

High-throughput

0.618

High

1334138

PD1L1
Programmed cell death 1 ligand 1

1

5

High-throughput

0.618

High

1334140

DNJB9
DnaJ homolog subfamily B member 9

1

20

High-throughput

0.618

High

1334141

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.618

High

300798

KRT38
Keratin, type I cuticular Ha8

2

4

High-throughput

0.613

High

1334121

JMJD8
JmjC domain-containing protein 8

2

3

High-throughput

0.611

High

1086425

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

14

Small-scale

0.586

High

535301

BIP
Endoplasmic reticulum chaperone BiP

2

17

High-throughput

0.584

High

1334116

CALR3
Calreticulin-3

2

20

High-throughput

0.584

High

1277316

NT2NA
Notch homolog 2 N-terminal-like protein A

2

5

High-throughput

0.576

High

540263

SPTB1
Spectrin beta chain, erythrocytic

2

1

High-throughput

0.558

High

1199997

KLH26
Kelch-like protein 26

2

2

High-throughput

0.558

High

1245313

WDR59
GATOR2 complex protein WDR59

2

14

High-throughput

0.558

High

1308462

VRK3
Serine/threonine-protein kinase VRK3

2

3

High-throughput

0.558

High

1334143

UBQL2
Ubiquilin-2

2

3

High-throughput

0.553

High

820691

CEAM6
Cell adhesion molecule CEACAM6

1

13

High-throughput

0.553

High

947232

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.553

High

1334117

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

20

High-throughput

0.553

High

783624

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

7

High-throughput

0.536

High

1051270

KPCZ
Protein kinase C zeta type

1

5

High-throughput

0.536

High

1334108

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.536

High

1334144

DS13B
Dual specificity protein phosphatase 13B

2

8

High-throughput

0.533

High

1334148

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

2

1

High-throughput

0.526

High

1060684

SOS1
Son of sevenless homolog 1

2

5

High-throughput

0.521

High

693033

DPP4
Dipeptidyl peptidase 4

1

10

High-throughput

0.515

High

520205

ANDR
Androgen receptor

1

10

Small-scale

0.512

High

422619

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

186857

FOXN1
Forkhead box protein N1

1

1

High-throughput

0.489

High

964676

DCAF7
DDB1- and CUL4-associated factor 7

1

14

High-throughput

0.489

High

1054746

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

1153007

MYLK
Myosin light chain kinase, smooth muscle

1

7

High-throughput

0.489

High

1260474

MTSS2
Protein MTSS 2

1

3

High-throughput

0.489

High

1295630

MYLK4
Myosin light chain kinase family member 4

1

9

High-throughput

0.489

High

1334111

HDA10
Polyamine deacetylase HDAC10

1

10

High-throughput

0.489

High

1334127

KPCD2
Serine/threonine-protein kinase D2

1

3

High-throughput

0.489

High

1334134

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

1334135

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.489

High

221157

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.481

High

1334110

LHX4
LIM/homeobox protein Lhx4

1

1

High-throughput

0.481

High

170235

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

218480

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

229758

CALU
Calumenin

1

16

High-throughput

0.479

High

242302

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

353449

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.479

High

363576

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

369369

A1AT
Alpha-1-antitrypsin

1

3

Small-scale

0.479

High

372599

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

377657

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

401154

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

412267

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

439791

INSR
Insulin receptor

1

20

High-throughput

0.479

High

537530

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

607616

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

16

High-throughput

0.479

High

614709

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

13

High-throughput

0.479

High

616204

PGAM1
Phosphoglycerate mutase 1

1

7

High-throughput

0.479

High

720276

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.479

High

761769

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

762352

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

2

High-throughput

0.479

High

867279

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

876707

HSP13
Heat shock 70 kDa protein 13

1

10

High-throughput

0.479

High

934867

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.479

High

951272

SC61B
Protein transport protein Sec61 subunit beta

1

8

High-throughput

0.479

High

1107025

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1113722

CUL3
Cullin-3

1

15

High-throughput

0.479

High

1207826

EPHAA
Ephrin type-A receptor 10

1

20

High-throughput

0.479

High

1312559

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

5

High-throughput

0.479

High

1334103

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1334109

TP4A1
Protein tyrosine phosphatase type IVA 1

1

9

High-throughput

0.479

High

1334112

LRC59
Leucine-rich repeat-containing protein 59

1

8

High-throughput

0.479

High

1334115

ERO1A
ERO1-like protein alpha

1

10

High-throughput

0.479

High

1334123

SEC62
Translocation protein SEC62

1

4

High-throughput

0.479

High

1334139

VAPA
Vesicle-associated membrane protein-associated protein A

1

7

High-throughput

0.479

High

275445

Z780A
Zinc finger protein 780A

1

8

High-throughput

0.470

High

1217886

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

5

High-throughput

0.470

High

1334122

NODAL
Nodal homolog

1

2

High-throughput

0.470

High

248002

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

279424

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

619316

LFA3
Lymphocyte function-associated antigen 3

1

0

High-throughput

0.458

High

635349

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.458

High

978612

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

1334118

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.458

High

185858

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

17

High-throughput

0.457

High

1334105

PJA1
E3 ubiquitin-protein ligase Praja-1

1

6

Small-scale

0.457

High

384179

CO1A1
Collagen alpha-1(I) chain

1

8

Small-scale

0.445

High

530089

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

591738

H2AX
Histone H2AX

1

3

High-throughput

0.445

High

1060372

SLC31
Amino acid transporter heavy chain SLC3A1

1

5

High-throughput

0.445

High

1209401

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

783337

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.439

High

949939

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

950337

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.439

High

950583

KR108
Keratin-associated protein 10-8

1

20

High-throughput

0.439

High

950834

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.439

High

1151585

TRIP6
Thyroid receptor-interacting protein 6

1

2

High-throughput

0.439

High

1230146

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.439

High

1311441

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.439

High

1334119

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

1

High-throughput

0.439

High

1334125

KR412
Keratin-associated protein 4-12

1

20

High-throughput

0.439

High

1334126

KRA42
Keratin-associated protein 4-2

1

20

High-throughput

0.439

High

1334131

GO45
Golgin-45

1

1

High-throughput

0.439

High

106289

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

227616

SPOP
Speckle-type POZ protein

1

5

High-throughput

0.437

High

239862

PCDH7
Protocadherin-7

1

3

High-throughput

0.437

High

272324

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

285369

EED
Polycomb protein EED

1

12

High-throughput

0.437

High

292178

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

4

High-throughput

0.437

High

315781

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.437

High

324988

HEXI1
Protein HEXIM1

1

4

High-throughput

0.437

High

404231

GCR
Glucocorticoid receptor

1

10

High-throughput

0.437

High

560455

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.437

High

564073

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.437

High

572945

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.437

High

606917

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.437

High

623447

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.437

High

731469

STIP1
Stress-induced-phosphoprotein 1

1

17

High-throughput

0.437

High

761264

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.437

High

932584

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

15

High-throughput

0.437

High

957440

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.437

High

965093

WDR5
WD repeat-containing protein 5

1

10

High-throughput

0.437

High

970793

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

1004838

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.437

High

1035783

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.437

High

1049172

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.437

High

1117285

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

2

High-throughput

0.437

High

1134991

CUL7
Cullin-7

1

4

High-throughput

0.437

High

1138406

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.437

High

1155549

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.437

High

1164054

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

18

High-throughput

0.437

High

1179112

TECT1
Tectonic-1

1

15

High-throughput

0.437

High

1180234

SMU1
WD40 repeat-containing protein SMU1

1

11

High-throughput

0.437

High

1238741

TECT3
Tectonic-3

1

15

High-throughput

0.437

High

1241696

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.437

High

1252134

SYNE3
Nesprin-3

1

8

High-throughput

0.437

High

1254677

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

1322518

TAGAP
T-cell activation Rho GTPase-activating protein

1

5

High-throughput

0.437

High

1334104

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.437

High

1334106

COP1
E3 ubiquitin-protein ligase COP1

1

16

High-throughput

0.437

High

1334107

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.437

High

1334113

MTMR8
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

1

3

High-throughput

0.437

High

1334114

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.437

High

1334124

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.437

High

1334130

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.437

High

1334132

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

1334133

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1334136

T106B
Transmembrane protein 106B

1

7

High-throughput

0.437

High

1334137

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

1334142

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1334145

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.437

High

1334146

FBW1A
F-box/WD repeat-containing protein 1A

1

10

High-throughput

0.437

High

1334147

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

1092595

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

430139

JUN
Transcription factor Jun

1

13

High-throughput

0.407

High

583582

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

8

High-throughput

0.407

High

653444

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

942753

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

9

High-throughput

0.407

High

943994

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.407

High

1218603

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.407

High

1227075

A16L1
Autophagy-related protein 16-1

1

17

High-throughput

0.407

High

887030

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.373

High

1191379

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1334120

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.251

Low

194269

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

1151357

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.249

Low

1308774

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low

1334129

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025