HitPredict

Interactor 1: IFNB (P01575)
Interferon beta (IFN-beta)
Gene: Ifnb1

Interactor 2: IRF3 (P70671)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	18583960, 16954376, 9541017, 18851954, 12821121, 20660350
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility supershift assay, electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043330 - response to exogenous dsRNA GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 182 Mm			1 419
+	Hs
		352755 IFNA1_HUMAN (6-181): 3.79e-87: 255: 24.58		IRF3_HUMAN (1-417): 0: 524: 71.06
+	Hs
		352770 IFNA2_HUMAN (13-182): 2.63e-86: 253: 26.74		IRF3_HUMAN (1-417): 0: 524: 71.06
+	Hs
		352844 IFN14_HUMAN (6-181): 1.29e-85: 251: 27.37		IRF3_HUMAN (1-417): 0: 524: 71.06
+	Hs
		352788 IFNA7_HUMAN (6-181): 5.01e-85: 250: 24.58		IRF3_HUMAN (1-417): 0: 524: 71.06
+	Mm
		427402 IFNA4_MOUSE (6-180): 7.74e-70: 211: 21.35		IRF3_MOUSE (1-419): 0: 560: 100.00
+	Hs
		352753 IFNA1_HUMAN (6-181): 3.79e-87: 255: 24.58		IRF5_HUMAN (2-414): 1.18e-154: 448: 27.04
+	Hs
		352842 IFN14_HUMAN (6-181): 1.29e-85: 251: 27.37		IRF5_HUMAN (2-414): 1.18e-154: 448: 27.04
+	Mm
		427400 IFNA4_MOUSE (6-180): 7.74e-70: 211: 21.35		IRF5_MOUSE (2-414): 1.28e-146: 427: 27.04
+	Hs
		352758 IFNA1_HUMAN (6-181): 3.79e-87: 255: 24.58		IRF7_HUMAN (4-376): 1.83e-121: 363: 25.60
+	Hs
		352775 IFNA2_HUMAN (13-182): 2.63e-86: 253: 26.74		IRF7_HUMAN (4-376): 1.83e-121: 363: 25.60
+	Mm
		427399 IFNA4_MOUSE (6-180): 7.74e-70: 211: 21.35		IRF8_MOUSE (7-380): 8.09e-139: 405: 26.45
+	Hs
		352848 IFN14_HUMAN (6-181): 1.29e-85: 251: 27.37		IRF7_HUMAN (4-376): 1.83e-121: 363: 25.60
+	Hs
		352791 IFNA7_HUMAN (6-181): 5.01e-85: 250: 24.58		IRF7_HUMAN (4-376): 1.83e-121: 363: 25.60
+	Hs
		352878 IFNB_HUMAN (1-182): 2.31e-66: 202: 49.20		IRF8_HUMAN (7-380): 2.33e-138: 404: 26.82
+	Mm
		427401 IFNA4_MOUSE (6-180): 7.74e-70: 211: 21.35		IRF7_MOUSE (2-376): 3.98e-131: 386: 28.88
+	Hs
		352745 IFNA1_HUMAN (6-181): 3.79e-87: 255: 24.58		IRF1_HUMAN (1-200): 1.56e-65: 214: 27.67
+	Hs
		352766 IFNA2_HUMAN (13-182): 2.63e-86: 253: 26.74		IRF1_HUMAN (1-200): 1.56e-65: 214: 27.67
+	Hs
		352837 IFN14_HUMAN (6-181): 1.29e-85: 251: 27.37		IRF1_HUMAN (1-200): 1.56e-65: 214: 27.67
+	Hs
		352861 IFNB_HUMAN (1-182): 2.31e-66: 202: 49.20		IRF1_HUMAN (1-200): 1.56e-65: 214: 27.67
+	Hs
		352862 IFNB_HUMAN (1-182): 2.31e-66: 202: 49.20		IRF2_HUMAN (1-116): 3.17e-48: 169: 33.90