HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22199229, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 131 Sc			1 1230
+	Sc
		355931 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		SMC3_YEAST (1-1230): 4.94e-108: 370: 100.00
+	Hs
		1274480 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20
+	Hs
		241662 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20
+	Hs
		420896 H2B1J_HUMAN (7-128): 5.77e-46: 146: 70.16		SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20
+	Hs
		918774 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20
+	Hs
		311555 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMC2_HUMAN (1-1229): 1.89e-77: 281: 19.00
+	Hs
		1057346 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41
+	Hs
		707632 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41
+	Sc
		355421 H2B1_YEAST (1-131): 2.54e-44: 143: 100.00		SMC1_YEAST (2-1215): 4.84e-68: 253: 16.53
+	Hs
		1087272 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMC1B_HUMAN (2-1228): 1.12e-66: 248: 15.27
+	Sc
		355483 H2B1_YEAST (1-131): 2.54e-44: 143: 100.00		SMC2_YEAST (1-1210): 3.6e-64: 240: 18.41