HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: SET1 (Q5LJZ2)
Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354)
Gene: SET1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21694722
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 1641
+	Hs
		934804 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59
+	Hs
		1079993 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59
+	Hs
		935204 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SETD2_HUMAN (1097-1640): 6.27e-83: 305: 13.71
+	At
		886462 H33_ARATH (1-136): 4.35e-62: 188: 96.32		SUVH4_ARATH (1090-1640): 3.34e-87: 300: 15.01
+	Hs
		934681 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03
+	Hs
		975268 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03
+	Hs
		165661 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SET1A_HUMAN (1199-1641): 2.01e-74: 277: 40.22
+	Hs
		203659 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV91_HUMAN (1288-1640): 1.21e-80: 274: 15.80
+	Hs
		935276 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		ASH1L_HUMAN (1007-1640): 8.57e-72: 269: 13.76
+	Hs
		935237 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV92_HUMAN (1297-1641): 1.17e-76: 262: 15.39
+	Hs
		935368 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65
+	Hs
		331780 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD2_HUMAN (1382-1640): 5.01e-67: 252: 22.43
+	Hs
		331823 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		NSD2_HUMAN (1382-1640): 5.01e-67: 252: 22.43
+	Hs
		935129 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD1_HUMAN (1398-1640): 6.06e-66: 250: 23.08
+	Hs
		935205 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD3_HUMAN (1398-1640): 6.97e-65: 245: 22.67
+	Hs
		935374 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SET1B_HUMAN (27-310): 6.68e-62: 237: 25.90
+	Hs
		935251 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT1_HUMAN (1376-1637): 4.74e-62: 236: 18.49
+	Hs
		152625 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2D_HUMAN (1405-1641): 5.95e-61: 234: 37.76
+	Hs
		935004 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2C_HUMAN (1250-1641): 1.99e-57: 223: 27.41
+	Hs
		935270 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT5A_HUMAN (1277-1619): 8.23e-62: 219: 19.37