HitPredict

Interactor 1: CO1A1 (P02452)
Collagen alpha-1(I) chain (Alpha-1 type I collagen)
Gene: COL1A1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19558215
Identification Methods	nucleic acid uv cross-linking assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0010718 - positive regulation of epithelial to mesenchymal transition GO:0045893 - positive regulation of DNA-templated transcription GO:0046872 - metal ion binding GO:0071333 - cellular response to glucose stimulus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1464 Hs			1 467
+	Mm
		503177 CO1A1_MOUSE (53-1464): 0: 665: 92.92		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Hs
		358494 CO1A1_HUMAN (1-1464): 0: 674: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		503178 CO1A1_MOUSE (53-1464): 0: 665: 92.92		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Mm
		435995 CO3A1_MOUSE (39-1464): 1.94e-166: 541: 59.41		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Mm
		435996 CO3A1_MOUSE (39-1464): 1.94e-166: 541: 59.41		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Hs
		358510 CO1A1_HUMAN (1-1464): 0: 674: 100.00		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Mm
		435992 CO3A1_MOUSE (39-1464): 1.94e-166: 541: 59.41		SMAD1_MOUSE (1-467): 0: 566: 55.42
+	Mm
		503173 CO1A1_MOUSE (53-1464): 0: 665: 92.92		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46
+	Mm
		192481 CO1A1_MOUSE (53-1464): 0: 665: 92.92		SMAD7_MOUSE (13-443): 5.17e-112: 338: 25.00
+	Mm
		435994 CO3A1_MOUSE (39-1464): 1.94e-166: 541: 59.41		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46
+	Mm
		192480 CO3A1_MOUSE (39-1464): 1.94e-166: 541: 59.41		SMAD7_MOUSE (13-443): 5.17e-112: 338: 25.00
+	Mm
		291325 CO5A1_MOUSE (3-481): 3.79e-20: 99.9: 34.00		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Mm
		291326 CO5A1_MOUSE (3-481): 3.79e-20: 99.9: 34.00		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Mm
		291322 CO5A1_MOUSE (3-481): 3.79e-20: 99.9: 34.00		SMAD1_MOUSE (1-467): 0: 566: 55.42
+	Mm
		291323 CO5A1_MOUSE (3-481): 3.79e-20: 99.9: 34.00		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46
+	Mm
		192478 CO5A1_MOUSE (3-481): 3.79e-20: 99.9: 34.00		SMAD7_MOUSE (13-443): 5.17e-112: 338: 25.00