Protein: HCD2
3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51, EC 1.1.1.62) (3-hydroxyacyl-CoA dehydrogenase type II) (Hydroxysteroid dehydrogenase) (EC 1.1.1.-, EC 1.1.1.53) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH)

Gene: HCD2, scu
Organism: Drosophila melanogaster
Interactions: 232
UniProt ID: O18404

Gene Ontology (top 5):
GO:0003857 - (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0006631 - fatty acid metabolic process
GO:0006637 - acyl-CoA metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

197766

MRRP1
Mitochondrial ribonuclease P protein 1 homolog

2

1

Small-scale

0.775

High

197895

DHB4
Peroxisomal multifunctional enzyme type 2

1

19

High-throughput

0.575

High

197837

Q9VEB1
Malate dehydrogenase, mitochondrial

2

2

High-throughput

0.571

High

197859

Q9VL70
HL08109p

2

3

High-throughput

0.571

High

197885

Q9VU35
10 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.571

High

197720

NDKA
Nucleoside diphosphate kinase

2

0

High-throughput

0.547

High

197731

CALR
Calreticulin

2

0

High-throughput

0.547

High

197790

Q8IRD3
Glutathione peroxidase

2

0

High-throughput

0.547

High

57493

A1ZB71
Glutathione S transferase E6

2

3

High-throughput

0.521

High

197295

O18335
Rab11

2

1

High-throughput

0.521

High

197713

O97102
Small ubiquitin-related modifier

2

1

High-throughput

0.521

High

197719

ALF
Fructose-bisphosphate aldolase

2

1

High-throughput

0.521

High

197722

ENO
Enolase

2

2

High-throughput

0.521

High

197723

PCNA
Proliferating cell nuclear antigen

2

1

High-throughput

0.521

High

197728

ANX10
Annexin B10

2

2

High-throughput

0.521

High

197734

UCHL
Ubiquitin carboxyl-terminal hydrolase

2

1

High-throughput

0.521

High

197738

MOEH
Moesin/ezrin/radixin homolog 1

2

1

High-throughput

0.521

High

197739

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

2

3

High-throughput

0.521

High

197742

PDI
Protein disulfide-isomerase

2

3

High-throughput

0.521

High

197759

NLP
Nucleoplasmin-like protein

2

1

High-throughput

0.521

High

197770

Q7JX87
1-Cys peroxiredoxin

2

7

High-throughput

0.521

High

197775

Q7K148
Proteasome subunit beta

2

2

High-throughput

0.521

High

197793

Q8MT58
Carnosine dipeptidase 2, isoform A

2

1

High-throughput

0.521

High

197795

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

1

High-throughput

0.521

High

197798

NACA
Nascent polypeptide-associated complex subunit alpha

2

1

High-throughput

0.521

High

197817

Q9V3V2
peptidylprolyl isomerase

2

3

High-throughput

0.521

High

197820

THIO2
Thioredoxin-2

2

2

High-throughput

0.521

High

197843

Q9VGK3
peptidylprolyl isomerase

2

3

High-throughput

0.521

High

197847

Q9VHN7
transketolase

2

1

High-throughput

0.521

High

197856

Q9VKW5
Prolyl endopeptidase

2

1

High-throughput

0.521

High

197869

Q9VPN5
Stress-induced-phosphoprotein 1

2

2

High-throughput

0.521

High

197876

Q9VRD6
NTF2-related export protein

2

1

High-throughput

0.521

High

197881

Q9VSL2
Glutathione S transferase O3

2

1

High-throughput

0.521

High

197883

Q9VTY2
Uncharacterized protein, isoform A

2

4

High-throughput

0.521

High

197890

Q9VW59
Rho GDP-dissociation inhibitor 3

2

1

High-throughput

0.521

High

197905

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

2

High-throughput

0.521

High

197753

Q0E8E8
Phosphate carrier protein, mitochondrial

1

2

High-throughput

0.508

High

197802

Q95RF6
LD34461p

1

1

High-throughput

0.479

High

197911

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

1

Small-scale

0.479

High

197855

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

121154

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

197746

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

197751

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.445

High

197765

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

5

High-throughput

0.445

High

197771

Q7JXC4
CG6459 protein

1

1

High-throughput

0.445

High

197786

QPCT2
Glutaminyl-peptide cyclotransferase

1

1

High-throughput

0.445

High

197799

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.445

High

197840

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.445

High

197841

Q9VG31
Malic enzyme

1

1

High-throughput

0.445

High

197854

Q9VKB0
threonine--tRNA ligase

1

2

High-throughput

0.445

High

197858

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

6

High-throughput

0.445

High

197902

Q9W022
GEO01508p1

1

4

High-throughput

0.445

High

197910

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.445

High

48405

A0AVV3
Dorsal root ganglia homeobox protein

1

3

High-throughput

0.439

High

52146

A1Z6P8
Exchange protein directly activated by cAMP, isoform E

1

1

High-throughput

0.439

High

197922

X2JCD3
Uncharacterized protein, isoform D

1

2

High-throughput

0.439

High

120731

M9PE30
Transgelin

1

3

High-throughput

0.437

High

197709

O61604
Fimbrin

1

1

High-throughput

0.437

High

197758

DIAP2
Death-associated inhibitor of apoptosis 2

1

3

High-throughput

0.437

High

197773

Q7K0B6
Glutathione S transferase T1

1

3

High-throughput

0.437

High

197785

Q86BM5
A kinase anchor protein 200, isoform D

1

1

High-throughput

0.437

High

197791

Q8IRS7
Ciboulot, isoform C

1

1

High-throughput

0.437

High

197800

NFKB1
Nuclear factor NF-kappa-B p110 subunit

1

2

High-throughput

0.437

High

197805

PGPLC
Peptidoglycan-recognition protein LC

1

2

High-throughput

0.437

High

197816

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.437

High

197844

Q9VGM2
Fatty acid-binding protein, muscle

1

1

High-throughput

0.437

High

197896

PGPLE
Peptidoglycan-recognition protein LE

1

2

High-throughput

0.437

High

197900

Q9VYR1
Regucalcin

1

1

High-throughput

0.437

High

197712

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

197747

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.426

High

197748

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.426

High

197754

Q0E8X8
ATP synthase F1 subunit epsilon

1

0

High-throughput

0.426

High

197756

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.426

High

197757

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.426

High

197825

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

197833

ORN
Probable oligoribonuclease

1

0

High-throughput

0.426

High

197836

Q9VD29
small monomeric GTPase

1

0

High-throughput

0.426

High

197851

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

197852

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

197871

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.426

High

197875

Q9VRD4
Uncharacterized protein, isoform A

1

0

High-throughput

0.426

High

197880

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

197908

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.426

High

197913

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.426

High

197778

Q7K3Z6
Exchange protein directly activated by cAMP, isoform D

1

1

High-throughput

0.417

High

197884

Q9VU13
LD45603p

1

2

High-throughput

0.417

High

53946

A1Z892
1-Cys peroxiredoxin

1

7

High-throughput

0.407

High

197402

O18338
LD44762p

1

1

High-throughput

0.407

High

197707

VINC
Vinculin

1

2

High-throughput

0.407

High

197714

O97121
cystathionine gamma-lyase

1

1

High-throughput

0.407

High

197715

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

1

High-throughput

0.407

High

197716

O97428
Ciboulot, isoform A

1

1

High-throughput

0.407

High

197718

HP1
Heterochromatin protein 1

1

3

High-throughput

0.407

High

197721

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.407

High

197724

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.407

High

197726

JANA
Sex-regulated protein janus-A

1

1

High-throughput

0.407

High

197727

ANXB9
Annexin B9

1

2

High-throughput

0.407

High

197729

PSA71
Proteasome subunit alpha type-7-1

1

3

High-throughput

0.407

High

197732

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.407

High

197733

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

197735

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.407

High

197736

PSB1
Proteasome subunit beta type-1

1

3

High-throughput

0.407

High

197737

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.407

High

197750

HMGD
High mobility group protein D

1

1

High-throughput

0.407

High

197752

GRAP
Growth factor receptor-bound protein 2

1

1

High-throughput

0.407

High

197755

Q0KHS0
Katanin p80 WD40 repeat-containing subunit B1

1

4

High-throughput

0.407

High

197761

Q3YMU0
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

197763

Q6QU65
ADAM metalloprotease

1

1

High-throughput

0.407

High

197764

Q76NR6
Regucalcin

1

1

High-throughput

0.407

High

197767

Q7JVH6
LD24696p

1

4

High-throughput

0.407

High

197768

Q7JVZ8
Glutathione S transferase E11, isoform A

1

3

High-throughput

0.407

High

197774

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.407

High

197777

Q7K3J0
T-complex protein 1 subunit theta

1

2

High-throughput

0.407

High

197781

Q7KKI0
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

197782

TERA
Transitional endoplasmic reticulum ATPase TER94

1

1

High-throughput

0.407

High

197787

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.407

High

197789

Q8IQZ7
FI19014p1

1

1

High-throughput

0.407

High

197796

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.407

High

197797

Q8T0L3
E1 ubiquitin-activating enzyme

1

2

High-throughput

0.407

High

197801

PSA5
Proteasome subunit alpha type-5

1

2

High-throughput

0.407

High

197810

Q9I7K7
Arrestin C-terminal-like domain-containing protein

1

1

High-throughput

0.407

High

197821

PDIA6
Protein disulfide-isomerase A6 homolog

1

2

High-throughput

0.407

High

197822

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.407

High

197826

Q9VAC4
GEO09167p1

1

1

High-throughput

0.407

High

197829

Q9VAY2
Heat shock protein 83

1

1

High-throughput

0.407

High

197830

Q9VB96
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

197831

Q9VBR6
RE74917p

1

1

High-throughput

0.407

High

197835

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

197838

FLNA
Filamin-A

1

2

High-throughput

0.407

High

197849

Q9VHX4
LD24679p

1

4

High-throughput

0.407

High

197853

Q9VJD4
LD24721p

1

3

High-throughput

0.407

High

197857

EF1D
Probable elongation factor 1-delta

1

2

High-throughput

0.407

High

197860

FKB59
FK506-binding protein 59

1

2

High-throughput

0.407

High

197861

Q9VL89
Methionine aminopeptidase 2

1

1

High-throughput

0.407

High

197863

AK200
A-kinase anchor protein 200

1

2

High-throughput

0.407

High

197866

PSB4
Proteasome subunit beta type-4

1

6

High-throughput

0.407

High

197868

Q9VP52
GH24315p

1

1

High-throughput

0.407

High

197874

Q9VQL1
serine--tRNA ligase

1

4

High-throughput

0.407

High

197877

Q9VRL1
GEO06356p1

1

3

High-throughput

0.407

High

197878

Q9VRP2
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

197886

WDR1
Actin-interacting protein 1

1

2

High-throughput

0.407

High

197889

Q9VVL7
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.407

High

197891

Q9VW70
FI21813p1

1

1

High-throughput

0.407

High

197898

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.407

High

197901

Q9VZI1
Transgelin

1

3

High-throughput

0.407

High

197912

WUHO
tRNA

1

2

High-throughput

0.407

High

197914

Q9W478
RE43153p

1

1

High-throughput

0.407

High

197915

PSB3
Proteasome subunit beta type-3

1

3

High-throughput

0.407

High

197916

Q9XYZ9
Glutathione S transferase E12, isoform A

1

3

High-throughput

0.407

High

197918

PSA6
Proteasome subunit alpha type-6

1

3

High-throughput

0.407

High

197920

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.407

High

197921

Q9Y170
Sex-regulated protein janus-B

1

1

High-throughput

0.407

High

57723

A1ZB77
Uncharacterized protein, isoform J

2

0

High-throughput

0.298

High

194975

O16043
Anon1A4

2

0

High-throughput

0.298

High

197717

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.298

High

197730

PROF
Profilin

2

0

High-throughput

0.298

High

197749

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.298

High

197804

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.298

High

197806

IF5A
Eukaryotic translation initiation factor 5A

2

0

High-throughput

0.298

High

197812

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

0

High-throughput

0.298

High

197819

Q9V3V9
Endonuclease G inhibitor, isoform A

2

0

High-throughput

0.298

High

197828

Q9VAN7
Phosphoglycerate mutase

2

0

High-throughput

0.298

High

197870

Q9VPX6
Adenylyl cyclase-associated protein

2

0

High-throughput

0.298

High

197873

BACC
Bacchus

2

0

High-throughput

0.298

High

197917

Q9XZ57
Eb1, isoform E

2

0

High-throughput

0.298

High

56612

A1ZAC8
Uncharacterized protein, isoform B

1

0

High-throughput

0.265

Low

197769

Q7JWN2
RE25177p

1

0

High-throughput

0.265

Low

197872

Q9VQ94
LP05220p

1

0

High-throughput

0.265

Low

197894

Q9VXA7
C2H2-type domain-containing protein

1

0

High-throughput

0.265

Low

55052

A1Z921
Frazzled, isoform B

1

0

Small-scale

0.249

Low

197762

Q6NQZ7
LD40663p

1

0

High-throughput

0.249

Low

197779

IMD
Protein immune deficiency

1

0

High-throughput

0.249

Low

197792

CASP8
Caspase-8

1

0

High-throughput

0.249

Low

197807

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.249

Low

197814

FADD
Fas-associated death domain protein

1

0

High-throughput

0.249

Low

197839

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

0

High-throughput

0.249

Low

53828

A1Z864
FI01421p

1

0

High-throughput

0.232

Low

86438

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

121608

M9PFR6
Multiprotein bridging factor 1, isoform E

1

0

High-throughput

0.232

Low

145943

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.232

Low

197708

LOK
Ovarian-specific serine/threonine-protein kinase Lok

1

0

High-throughput

0.232

Low

197710

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

197711

TRMB
tRNA

1

0

High-throughput

0.232

Low

197725

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

197740

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

197741

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.232

Low

197743

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

197744

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.232

Low

197745

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

197760

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.232

Low

197772

SEELE
Protein seele

1

0

High-throughput

0.232

Low

197776

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

197780

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

197783

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.232

Low

197784

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.232

Low

197788

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.232

Low

197794

Q8MYY7
RE44624p

1

0

High-throughput

0.232

Low

197803

FAXC
Failed axon connections

1

0

High-throughput

0.232

Low

197808

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.232

Low

197809

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

197811

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.232

Low

197813

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

197815

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

197818

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.232

Low

197823

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

0

High-throughput

0.232

Low

197824

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

197827

Q9VAG3
trypsin

1

0

High-throughput

0.232

Low

197832

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

197834

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

197842

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

197845

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.232

Low

197846

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.232

Low

197848

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.232

Low

197850

Q9VIC3
carboxylesterase

1

0

High-throughput

0.232

Low

197862

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.232

Low

197864

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

197865

GUAD
Guanine deaminase

1

0

High-throughput

0.232

Low

197867

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

197879

Q9VS98
LD12639p

1

0

High-throughput

0.232

Low

197882

Q9VTX2
RE32936p

1

0

High-throughput

0.232

Low

197887

Q9VUC1
Hsc70Cb, isoform A

1

0

High-throughput

0.232

Low

197888

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

197892

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

197893

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

197897

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.232

Low

197899

Q9VYB9
LP02557p

1

0

High-throughput

0.232

Low

197903

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.232

Low

197904

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.232

Low

197906

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.232

Low

197907

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.232

Low

197909

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

197919

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025