HitPredict

Interactor 1: CO2A1 (P02458)
Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
Gene: COL2A1

Interactor 2: CO8A1 (P27658)
Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]
Gene: COL8A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Collagen~Collagen
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0030020 - extracellular matrix structural constituent conferring tensile strength GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1487 Hs			1 744
+	Hs
		358610 CO2A1_HUMAN (1-1487): 0: 779: 100.00		Q4VAQ0_HUMAN (435-743): 6.44e-39: 151: 54.37
+	Hs
		358599 CO2A1_HUMAN (1-1487): 0: 779: 100.00		CO8A2_HUMAN (13-360): 7.22e-16: 83.8: 25.38
+	Hs
		358581 CO2A1_HUMAN (1-1487): 0: 779: 100.00		CO2A1_HUMAN (11-281): 2.59e-15: 82.6: 21.43
+	Hs
		70495 CO2A1_HUMAN (1-1487): 0: 779: 100.00		C1T9B_HUMAN (49-187): 2.92e-13: 73.7: 25.53
+	Hs
		358596 CO2A1_HUMAN (1-1487): 0: 779: 100.00		CO9A1_HUMAN (118-413): 8.04e-12: 70.9: 35.48
+	Hs
		358590 CO2A1_HUMAN (1-1487): 0: 779: 100.00		C1T9A_HUMAN (94-244): 2.5e-11: 67.8: 38.46
+	Hs
		358440 CO2A1_HUMAN (1-1487): 0: 779: 100.00		CO1A1_HUMAN (10-209): 3.78e-09: 62.6: 21.10
+	Mm
		658795 CO2A1_MOUSE (1-1487): 0: 757: 95.09		CO2A1_MOUSE (11-201): 4.58e-12: 71.8: 16.60
+	Hs
		358624 CO3A1_HUMAN (1-1487): 1.29e-178: 574: 59.76		CO3A1_HUMAN (43-631): 8.21e-24: 109: 30.21
+	Hs
		358629 CO3A1_HUMAN (1-1487): 1.29e-178: 574: 59.76		CO1A2_HUMAN (5-169): 4.4e-12: 71.8: 23.53
+	Dm
		435987 Q9VMV5_DROME (2-886): 1.88e-103: 368: 35.26		CO4A1_DROME (2-266): 2.59e-26: 118: 27.07
+	Hs
		1047979 CO4A6_HUMAN (538-1295): 8.9e-71: 264: 31.78		Q4VAQ0_HUMAN (435-743): 6.44e-39: 151: 54.37
+	Hs
		358498 CO1A1_HUMAN (3-762): 1.62e-71: 266: 41.28		CO7A1_HUMAN (338-660): 5.55e-17: 88: 31.36
+	Hs
		358479 CO1A1_HUMAN (3-762): 1.62e-71: 266: 41.28		CO8A2_HUMAN (13-360): 7.22e-16: 83.8: 25.38
+	Hs
		626312 CO4A6_HUMAN (538-1295): 8.9e-71: 264: 31.78		CO8A2_HUMAN (13-360): 7.22e-16: 83.8: 25.38
+	Hs
		441046 CO4A2_HUMAN (476-1293): 9.27e-66: 248: 31.45		CO4A2_HUMAN (300-656): 1.54e-20: 99.6: 28.79
+	Hs
		358452 CO1A1_HUMAN (3-762): 1.62e-71: 266: 41.28		CO1A2_HUMAN (5-169): 4.4e-12: 71.8: 23.53
+	Hs
		358439 CO1A1_HUMAN (3-762): 1.62e-71: 266: 41.28		CO1A1_HUMAN (10-209): 3.78e-09: 62.6: 21.10
+	Hs
		358648 CO4A2_HUMAN (476-1293): 9.27e-66: 248: 31.45		CO4A1_HUMAN (338-661): 1.32e-13: 76.8: 33.82