Protein: IRF2
Interferon regulatory factor 2 (IRF-2)

Gene: IRF2
Organism: Homo sapiens
Interactions: 138
UniProt ID: P14316

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533865

IRF1
Interferon regulatory factor 1

4

16

Small-scale

0.878

High

571590

IRF8
Interferon regulatory factor 8

3

15

Small-scale

0.839

High

571617

I2BP2
Interferon regulatory factor 2-binding protein 2

5

5

Small-scale

0.728

High

571619

I2BP1
Interferon regulatory factor 2-binding protein 1

5

3

Small-scale

0.728

High

571561

C2TA
MHC class II transactivator

6

7

Small-scale

0.721

High

571589

FOXK2
Forkhead box protein K2

4

5

High-throughput

0.711

High

571635

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

4

6

High-throughput

0.704

High

571585

FOXK1
Forkhead box protein K1

3

6

High-throughput

0.686

High

378356

IFNB
Interferon beta

4

20

Small-scale

0.676

High

571645

HCFC2
Host cell factor 2

3

4

High-throughput

0.675

High

571588

MDM2
E3 ubiquitin-protein ligase Mdm2

2

2

Small-scale

0.643

High

571627

KAT2B
Histone acetyltransferase KAT2B

2

8

Small-scale

0.639

High

571577

HCFC1
Host cell factor 1

2

4

High-throughput

0.628

High

571614

TASO2
Protein TASOR 2

2

4

High-throughput

0.628

High

571558

CATS
Cathepsin S

3

3

Small-scale

0.609

High

571599

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.589

High

334148

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

3

High-throughput

0.586

High

571548

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

2

High-throughput

0.586

High

571593

TAP1
Antigen peptide transporter 1

3

3

Small-scale

0.585

High

571637

BRD7
Bromodomain-containing protein 7

1

16

Small-scale

0.552

High

571584

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.550

High

571607

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.541

High

571633

TRI55
Tripartite motif-containing protein 55

1

17

High-throughput

0.541

High

229408

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

1

High-throughput

0.536

High

486909

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.536

High

557822

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.536

High

559201

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.536

High

571566

CUX1
Homeobox protein cut-like 1

1

3

High-throughput

0.536

High

571574

DNLI3
DNA ligase 3

1

1

High-throughput

0.536

High

571579

HIRA
Protein HIRA

1

1

High-throughput

0.536

High

571586

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.536

High

571592

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.536

High

571595

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.536

High

571597

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

1

High-throughput

0.536

High

571601

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

571602

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

11

High-throughput

0.536

High

571605

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.536

High

571606

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.536

High

571612

CE170
Centrosomal protein of 170 kDa

1

5

High-throughput

0.536

High

571616

SKI3
Superkiller complex protein 3

1

2

High-throughput

0.536

High

571620

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.536

High

571642

CSN3
COP9 signalosome complex subunit 3

1

5

High-throughput

0.536

High

424312

IL4
Interleukin-4

1

3

Small-scale

0.515

High

571565

MYH9
Myosin-9

1

2

Small-scale

0.515

High

571581

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

571603

CASP8
Caspase-8

1

3

Small-scale

0.515

High

71697

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.513

High

212870

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

428052

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.513

High

443151

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.513

High

445711

ENOA
Alpha-enolase

1

0

High-throughput

0.513

High

459433

PROF1
Profilin-1

1

0

High-throughput

0.513

High

469248

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.513

High

476075

ANXA5
Annexin A5

1

0

High-throughput

0.513

High

571552

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.513

High

571553

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

571559

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.513

High

571563

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.513

High

571564

RFC2
Replication factor C subunit 2

1

0

High-throughput

0.513

High

571571

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.513

High

571573

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

571575

EMD
Emerin

1

0

High-throughput

0.513

High

571583

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.513

High

571600

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

571618

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

571621

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.513

High

571624

TITIN
Titin

1

0

High-throughput

0.513

High

571625

LAR4B
La-related protein 4B

1

0

High-throughput

0.513

High

571629

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.513

High

571630

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.513

High

571631

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.513

High

571634

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.513

High

571636

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.513

High

571643

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.513

High

571644

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

571549

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.501

High

571551

SPI1
Transcription factor PU.1

1

10

Small-scale

0.501

High

571555

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.501

High

571594

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

571626

KAT2A
Histone acetyltransferase KAT2A

1

14

Small-scale

0.501

High

571646

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

2

High-throughput

0.494

High

61416

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.489

High

571598

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.489

High

571611

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.489

High

571628

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

421426

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

191203

TLR3
Toll-like receptor 3

1

13

Small-scale

0.479

High

193195

SOCS1
Suppressor of cytokine signaling 1

1

8

Small-scale

0.479

High

358600

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.479

High

390382

CXL10
C-X-C motif chemokine 10

1

10

Small-scale

0.479

High

403789

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

407379

K2C1
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.479

High

425288

ISG15
Ubiquitin-like protein ISG15

1

10

Small-scale

0.479

High

461097

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

468020

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

519325

MYB
Transcriptional activator Myb

1

2

Small-scale

0.479

High

571547

INGR1
Interferon gamma receptor 1

1

3

Small-scale

0.479

High

571550

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

571554

NUCL
Nucleolin

1

1

Small-scale

0.479

High

571556

NF1
Neurofibromin

1

2

Small-scale

0.479

High

571560

GBP1
Guanylate-binding protein 1

1

9

Small-scale

0.479

High

571562

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

571567

PSB10
Proteasome subunit beta type-10

1

9

Small-scale

0.479

High

571569

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

571570

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.479

High

571587

TF2B
Transcription initiation factor IIB

1

2

Small-scale

0.479

High

571591

DYST
Dystonin

1

1

Small-scale

0.479

High

571596

UBE3A
Ubiquitin-protein ligase E3A

1

6

Small-scale

0.479

High

571604

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

571640

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

571641

STAG3
Cohesin subunit SA-3

1

1

High-throughput

0.479

High

561003

IL7
Interleukin-7

1

2

Small-scale

0.470

High

116425

H6VRG2
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.445

High

571557

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.445

High

571568

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

1

High-throughput

0.445

High

571578

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.445

High

571582

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

1

High-throughput

0.445

High

571608

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.445

High

571613

WLS
Protein wntless homolog

1

0

Small-scale

0.438

High

158931

CXL11
C-X-C motif chemokine 11

1

10

Small-scale

0.437

High

416946

CY24B
NADPH oxidase 2

1

3

Small-scale

0.437

High

465930

CO1A2
Collagen alpha-2(I) chain

1

1

Small-scale

0.437

High

571576

TNF10
Tumor necrosis factor ligand superfamily member 10

1

7

Small-scale

0.437

High

571580

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.437

High

571615

ERAP2
Endoplasmic reticulum aminopeptidase 2

1

2

Small-scale

0.437

High

104024

F5GXY2
L-lactate dehydrogenase A chain

1

2

High-throughput

0.407

High

61896

GTPBA
GTP-binding protein 10

1

0

High-throughput

0.279

Low

275613

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.279

Low

571572

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.279

Low

571610

LSM12
Protein LSM12

1

0

High-throughput

0.279

Low

571622

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

571623

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.279

Low

571632

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.279

Low

571638

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

571639

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

476491

STS
Steryl-sulfatase

1

0

High-throughput

0.249

Low

571609

TPD53
Tumor protein D53

1

0

High-throughput

0.249

Low

516935

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025