HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	23074197, 23049853
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 303
+	Hs
		358982 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Mm
		621297 CRYAB_MOUSE (1-175): 8.71e-66: 200: 97.71		CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92
+	Hs
		358993 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28
+	Mm
		139736 CRYAB_MOUSE (1-175): 8.71e-66: 200: 97.71		CASP6_MOUSE (56-301): 9.58e-104: 305: 38.82
+	Hs
		388281 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		358983 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASP2_HUMAN (54-301): 2.1e-96: 293: 29.12
+	Hs
		359019 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		358992 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		388340 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CASP9_HUMAN (56-301): 2.27e-91: 279: 30.91
+	Hs
		359033 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CASPC_HUMAN (71-301): 2.15e-70: 222: 22.80