HitPredict

Interactor 1: K2C6A (P02538)
Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)
Gene: KRT6A

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 564 Hs			1 1480
+	Hs
		528683 K22E_HUMAN (135-479): 3.33e-173: 506: 72.75		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		408988 K2C8_HUMAN (135-511): 1.1e-163: 476: 68.70		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		444525 K2C7_HUMAN (103-534): 9.71e-159: 463: 63.99		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Mm
		514315 K2C8_MOUSE (80-531): 7.19e-164: 477: 59.03		CFTR_MOUSE (1-1468): 0: 957: 78.29
+	Hs
		380546 K2C1_HUMAN (128-494): 4.07e-107: 336: 73.30		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529780 KRT84_HUMAN (1-558): 6.5e-103: 324: 51.69		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		318772 K2C75_HUMAN (3-564): 4.11e-101: 318: 67.79		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		380440 K2C6B_HUMAN (1-499): 1.46e-91: 293: 98.60		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528760 K2C6C_HUMAN (1-499): 3.56e-91: 292: 98.40		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528963 KRT85_HUMAN (1-534): 2.29e-90: 289: 47.85		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529119 KRT81_HUMAN (46-560): 2.19e-90: 289: 46.82		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		213928 KRT86_HUMAN (46-544): 9.13e-88: 281: 47.80		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528450 K2C5_HUMAN (3-479): 1.58e-84: 276: 80.75		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529130 K2C72_HUMAN (79-554): 7.83e-78: 256: 60.29		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529332 K2C74_HUMAN (3-557): 5.74e-77: 254: 51.89		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529349 K2C1B_HUMAN (56-494): 7.34e-66: 226: 62.05		CFTR_HUMAN (1-1480): 0: 1031: 100.00