HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	20618440, 15161933
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 245
+	Hs
		380460 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		359838 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		595099 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		595184 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Mm
		250868 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		1433S_MOUSE (1-232): 2e-106: 309: 72.65
+	Mm
		821702 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		1433G_MOUSE (1-242): 5.48e-105: 305: 70.33
+	Hs
		443445 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		443346 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		443452 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Mm
		372933 GFAP_MOUSE (27-427): 7.43e-30: 124: 28.68		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	Hs
		443356 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		569050 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		569067 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Rn
		677657 VIME_RAT (27-389): 1.81e-31: 130: 28.93		1433B_RAT (1-242): 9.21e-126: 358: 81.41
+	Hs
		904437 KRT85_HUMAN (25-387): 4.71e-48: 178: 24.93		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		905163 KRT82_HUMAN (23-387): 1.44e-44: 168: 23.84		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		904944 KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		443357 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		443469 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		443441 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33