Protein: KS6A5
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)

Gene: KS6A5, RPS6KA5
Organism: Homo sapiens
Interactions: 118
UniProt ID: O75582

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001818 - negative regulation of cytokine production
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287702

MK14
Mitogen-activated protein kinase 14

7

20

Small-scale

0.966

High

287682

CSK2B
Casein kinase II subunit beta

3

9

High-throughput

0.863

High

287736

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

5

High-throughput

0.756

High

287658

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

287661

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

287664

RAGP1
Ran GTPase-activating protein 1

1

2

High-throughput

0.691

High

287674

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

287727

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.691

High

287681

ACTG
Actin, cytoplasmic 2

1

9

High-throughput

0.656

High

287722

ZN775
Zinc finger protein 775

1

2

High-throughput

0.656

High

287735

DJC11
DnaJ homolog subfamily C member 11

1

15

High-throughput

0.656

High

287653

CREB1
Cyclic AMP-responsive element-binding protein 1

3

5

Small-scale

0.655

High

287732

ROBO2
Roundabout homolog 2

1

0

High-throughput

0.622

High

287647

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

287648

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

287656

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

Small-scale

0.618

High

287703

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.618

High

287706

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.618

High

287729

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

287659

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.614

High

287670

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

3

Small-scale

0.611

High

287739

CTNA3
Catenin alpha-3

2

1

High-throughput

0.606

High

287730

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

2

High-throughput

0.601

High

287744

KDM3A
Lysine-specific demethylase 3A

1

1

Small-scale

0.586

High

287669

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.578

High

287675

RAB10
Ras-related protein Rab-10

1

0

High-throughput

0.578

High

287689

TF65
Transcription factor p65

1

10

Small-scale

0.578

High

287650

TAU
Microtubule-associated protein tau

1

10

Small-scale

0.550

High

287733

I17RB
Interleukin-17 receptor B

1

3

High-throughput

0.541

High

128110

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

4

High-throughput

0.536

High

129929

PGRC1
Membrane-associated progesterone receptor component 1

1

2

High-throughput

0.536

High

287672

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

3

High-throughput

0.536

High

287673

KAD2
Adenylate kinase 2, mitochondrial

1

3

High-throughput

0.536

High

287676

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.536

High

287677

DCAF7
DDB1- and CUL4-associated factor 7

1

9

High-throughput

0.536

High

287679

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.536

High

287680

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.536

High

287684

PRKDC
DNA-dependent protein kinase catalytic subunit

1

20

High-throughput

0.536

High

287692

TP53B
TP53-binding protein 1

1

4

High-throughput

0.536

High

287696

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.536

High

287697

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

7

High-throughput

0.536

High

287698

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

3

High-throughput

0.536

High

287699

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

287719

SPSB4
SPRY domain-containing SOCS box protein 4

1

13

High-throughput

0.536

High

287720

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

287731

MOV10
Helicase MOV-10

1

1

High-throughput

0.536

High

287740

CLC4A
C-type lectin domain family 4 member A

1

3

High-throughput

0.536

High

287741

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

3

High-throughput

0.536

High

287644

FINC
Fibronectin

1

0

High-throughput

0.519

High

287723

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.518

High

287645

GCR
Glucocorticoid receptor

1

20

Small-scale

0.515

High

287642

TNNC2
Troponin C, skeletal muscle

1

10

High-throughput

0.514

High

63921

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

182065

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.513

High

287640

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.513

High

287655

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

287657

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.513

High

287666

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.513

High

287667

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.513

High

287694

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

287713

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

287716

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

287725

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.513

High

287745

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

123206

PDLI1
PDZ and LIM domain protein 1

1

7

High-throughput

0.508

High

219837

SMAD6
Mothers against decapentaplegic homolog 6

1

10

High-throughput

0.508

High

287691

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.508

High

287700

ITSN1
Intersectin-1

1

6

High-throughput

0.508

High

287701

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.508

High

287709

RAI1
Retinoic acid-induced protein 1

1

5

High-throughput

0.508

High

287721

AKTS1
Proline-rich AKT1 substrate 1

1

4

High-throughput

0.508

High

287734

RN19A
E3 ubiquitin-protein ligase RNF19A

1

1

High-throughput

0.508

High

287641

CRYAA
Alpha-crystallin A chain

1

6

High-throughput

0.501

High

287643

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

287646

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

287654

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

7

Small-scale

0.501

High

287662

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.501

High

287668

ETV1
ETS translocation variant 1

1

3

Small-scale

0.501

High

287678

H4
Histone H4

1

1

Small-scale

0.501

High

287683

H31
Histone H3.1

1

12

Small-scale

0.501

High

287686

H11
Histone H1.1

1

2

Small-scale

0.501

High

287704

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.501

High

287708

H32
Histone H3.2

1

12

Small-scale

0.501

High

228770

SCO2
Protein SCO2 homolog, mitochondrial

1

1

High-throughput

0.489

High

287660

CALX
Calnexin

1

1

High-throughput

0.489

High

287665

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.489

High

287687

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

1

High-throughput

0.489

High

287712

GT251
Procollagen galactosyltransferase 1

1

1

High-throughput

0.489

High

287714

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

287728

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.489

High

287742

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.489

High

287685

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.486

High

287652

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

287663

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

287688

KMT2A
Histone-lysine N-methyltransferase 2A

1

8

Small-scale

0.479

High

287690

EP300
Histone acetyltransferase p300

1

12

Small-scale

0.479

High

287715

CBP
CREB-binding protein

1

12

Small-scale

0.479

High

287639

DDAH2
Putative hydrolase DDAH2

1

1

High-throughput

0.464

High

287693

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.464

High

287695

DPYL1
Dihydropyrimidinase-related protein 1

1

3

High-throughput

0.464

High

287738

MDFIC
MyoD family inhibitor domain-containing protein

1

0

High-throughput

0.460

High

287724

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

287717

BAD
Bcl2-associated agonist of cell death

1

5

Small-scale

0.457

High

138421

BIN1
Myc box-dependent-interacting protein 1

1

4

High-throughput

0.457

High

287651

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

Small-scale

0.445

High

287707

TXD11
Thioredoxin domain-containing protein 11

1

2

High-throughput

0.439

High

287726

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.282

High

71186

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

137584

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.279

Low

287638

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

287649

CLCB
Clathrin light chain B

1

0

High-throughput

0.279

Low

287671

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.279

Low

287705

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.279

Low

287710

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

287711

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

287718

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

287737

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.279

Low

287743

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025