HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: NUP98 (P52948)
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]
Gene: NUP98

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	24927568, 29568061, 34079125, 32344865, 22412018
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0031965 - nuclear membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 1817
+	Hs
		595161 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		NUP98_HUMAN (1-1817): 0: 1506: 100.00
+	Dr
		71416 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		E7F981_DANRE (1-1814): 0: 1221: 59.23
+	Ce
		106859 IFA4_CAEEL (5-548): 5.76e-69: 237: 25.18		NUP98_CAEEL (53-1723): 0: 760: 21.38
+	Ce
		106862 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		NUP98_CAEEL (53-1723): 0: 760: 21.38
+	Hs
		359762 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NU153_HUMAN (1-241): 3.42e-12: 74: 18.78
+	Hs
		359712 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NU214_HUMAN (162-710): 1.58e-09: 65.4: 16.40
+	Hs
		360279 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		P121A_HUMAN (2-326): 2.46e-09: 64.8: 14.42
+	Dr
		71429 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		F1Q712_DANRE (24-709): 4.19e-25: 116: 14.54
+	Dr
		71444 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		F1R543_DANRE (1-337): 1.3e-11: 72.1: 13.41
+	Ce
		1094244 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		Q9U3B9_CAEEL (217-384): 1.62e-09: 65: 26.11
+	Hs
		595144 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		NU153_HUMAN (1-241): 3.42e-12: 74: 18.78
+	Ce
		954505 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		P91457_CAEEL (7-386): 6.87e-09: 63.1: 18.09
+	Hs
		595357 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		P121A_HUMAN (2-326): 2.46e-09: 64.8: 14.42
+	Ce
		954500 IFB2_CAEEL (30-539): 5.39e-35: 141: 24.66		P91457_CAEEL (7-386): 6.87e-09: 63.1: 18.09
+	Hs
		535527 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		P121A_HUMAN (2-326): 2.46e-09: 64.8: 14.42