Protein: DYR
Dihydrofolate reductase (EC 1.5.1.3)

Gene: DYR, DHFR
Organism: Homo sapiens
Interactions: 134
UniProt ID: P00374

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0003729 - mRNA binding
GO:0004146 - dihydrofolate reductase activity
GO:0005542 - folic acid binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

359838

DYR2
Dihydrofolate reductase 2, mitochondrial

2

2

High-throughput

0.759

High

359889

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.618

High

359780

P53
Cellular tumor antigen p53

2

0

Small-scale

0.569

High

359805

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.561

High

359788

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.550

High

348298

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.547

High

231669

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.536

High

343542

OXSR1
Serine/threonine-protein kinase OSR1

1

1

High-throughput

0.536

High

359811

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

359819

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

2

High-throughput

0.536

High

359830

TRI65
E3 ubiquitin-protein ligase TRIM65

1

1

High-throughput

0.536

High

359831

DNMBP
Dynamin-binding protein

1

1

High-throughput

0.536

High

359832

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.536

High

359846

CTF18
Chromosome transmission fidelity protein 18 homolog

1

1

High-throughput

0.536

High

359864

METH
Methionine synthase

1

1

High-throughput

0.536

High

359870

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.536

High

359874

SHRPN
Sharpin

1

1

High-throughput

0.536

High

359888

TBD2B
TBC1 domain family member 2B

1

2

High-throughput

0.536

High

134514

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

158393

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

187432

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

254478

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

0

High-throughput

0.513

High

290281

KS6A4
Ribosomal protein S6 kinase alpha-4

1

0

High-throughput

0.513

High

322358

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

359791

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

359794

1433S
14-3-3 protein sigma

1

0

High-throughput

0.513

High

359799

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.513

High

359807

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.513

High

359808

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.513

High

359821

PKHG4
Puratrophin-1

1

0

High-throughput

0.513

High

359824

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.513

High

359827

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

359829

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

359837

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.513

High

359839

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

359840

TENS4
Tensin-4

1

0

High-throughput

0.513

High

359844

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

359854

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.513

High

359855

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

359858

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

359861

IF140
Intraflagellar transport protein 140 homolog

1

0

High-throughput

0.513

High

359872

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

359876

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.513

High

359880

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

359882

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

0

High-throughput

0.513

High

359890

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

359801

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

359802

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

Small-scale

0.501

High

359809

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.489

High

359820

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.489

High

359825

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.489

High

359845

SHKB1
SH3KBP1-binding protein 1

1

1

High-throughput

0.489

High

359851

N42L2
NEDD4-binding protein 2-like 2

1

1

High-throughput

0.489

High

359866

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.489

High

359867

KCD14
BTB/POZ domain-containing protein KCTD14

1

1

High-throughput

0.489

High

359873

DNAI2
Dynein axonemal intermediate chain 2

1

2

High-throughput

0.489

High

359875

KLK15
Kallikrein-15

1

1

High-throughput

0.489

High

359878

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

1

High-throughput

0.489

High

359887

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

Small-scale

0.480

High

240419

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

292051

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

359777

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

359778

RASN
GTPase NRas

1

1

High-throughput

0.479

High

359779

RASK
GTPase KRas

1

1

High-throughput

0.479

High

359785

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

359800

RND2
Rho-related GTP-binding protein RhoN

1

1

High-throughput

0.479

High

359810

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

359817

CDC37
Hsp90 co-chaperone Cdc37

1

1

Small-scale

0.479

High

359833

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.479

High

359836

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

359877

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

359782

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

359786

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

359793

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

359795

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

359812

CUL3
Cullin-3

1

0

High-throughput

0.458

High

359818

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

359850

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

359856

OPTN
Optineurin

1

0

High-throughput

0.458

High

359859

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

359879

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

359885

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

359826

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

2

High-throughput

0.445

High

359823

GKAP1
G kinase-anchoring protein 1

1

1

High-throughput

0.439

High

359787

H14
Histone H1.4

1

1

High-throughput

0.437

High

359790

H12
Histone H1.2

1

1

High-throughput

0.437

High

359813

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

359815

RHOH
Rho-related GTP-binding protein RhoH

1

1

High-throughput

0.437

High

359871

RHBT2
Rho-related BTB domain-containing protein 2

1

1

High-throughput

0.437

High

248825

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

359796

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.426

High

359798

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

359822

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

359828

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

359841

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.426

High

123207

PDLI1
PDZ and LIM domain protein 1

1

1

High-throughput

0.407

High

359781

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

74427

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

224457

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

298564

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

335296

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.279

Low

351769

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.279

Low

359783

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low

359789

EDN3
Endothelin-3

1

0

High-throughput

0.279

Low

359804

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

359806

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.279

Low

359814

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

359816

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.279

Low

359835

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

359842

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.279

Low

359843

BANP
Protein BANP

1

0

High-throughput

0.279

Low

359847

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

359848

MYO3B
Myosin-IIIb

1

0

High-throughput

0.279

Low

359852

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

359853

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.279

Low

359857

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

359862

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

359863

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

359865

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

359868

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.279

Low

359869

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

359881

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

359884

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

0

High-throughput

0.279

Low

359886

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.279

Low

359891

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

359792

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.249

Low

359797

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

359803

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

359834

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

359860

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

330012

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

359784

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

359849

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

359883

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025