HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25948554, 22412018
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 835
+	Mm
		821713 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Hs
		443490 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		359468 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		359683 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		359651 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RO52_HUMAN (104-502): 1.58e-48: 180: 12.94
+	Hs
		360383 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRIM6_HUMAN (113-494): 1.14e-47: 179: 10.23
+	Hs
		975756 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		318903 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		595104 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		170252 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		TIF1A_HUMAN (404-808): 1.31e-52: 200: 21.55
+	Hs
		318781 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TRI23_HUMAN (38-421): 2.37e-56: 205: 14.42
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (104-502): 1.58e-48: 180: 12.94
+	Hs
		443349 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		569112 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		422252 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56
+	Hs
		443833 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI36_HUMAN (50-425): 1.95e-52: 197: 14.87
+	Hs
		535556 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		TRIM9_HUMAN (93-529): 4.48e-51: 193: 13.30
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (104-502): 1.58e-48: 180: 12.94
+	Hs
		569118 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21
+	Hs
		422282 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		TRI55_HUMAN (41-610): 9.71e-50: 186: 14.21