HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: SUN2 (Q9UH99)
SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)
Gene: SUN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	28514442, 33961781, 30419336, 34079125, 32344865, 22555292, 19933576
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0007097 - nuclear migration GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 717
+	Mm
		821719 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		SUN2_MOUSE (1-717): 0: 834: 78.93
+	Hs
		299617 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SUN1_HUMAN (1-715): 0: 780: 33.51
+	Hs
		595461 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		SUN2_HUMAN (1-717): 0: 848: 100.00
+	Hs
		299633 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		SUN1_HUMAN (1-715): 0: 780: 33.51
+	Ce
		1093935 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		UNC84_CAEEL (476-715): 8.97e-79: 275: 31.73
+	Mm
		821739 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		SUN1_MOUSE (1-141): 1.57e-35: 146: 21.26
+	Ce
		1093999 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		SUN1_CAEEL (356-715): 2.97e-50: 184: 15.08