Protein: COX2
Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II)

Gene: COX2, mt:CoII
Organism: Drosophila melanogaster
Interactions: 126
UniProt ID: P00408

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005507 - copper ion binding
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0042773 - ATP synthesis coupled electron transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360577

Q9VIQ8
Cytochrome c oxidase subunit 4

2

1

High-throughput

0.737

High

144852

ATPG
ATP synthase subunit gamma, mitochondrial

2

1

High-throughput

0.571

High

360598

Q9VV75
AT02348p

2

3

High-throughput

0.571

High

355911

O96692
small monomeric GTPase

2

2

High-throughput

0.521

High

360508

RAP1
Ras-related protein Rap1

2

2

High-throughput

0.521

High

360513

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

2

1

High-throughput

0.521

High

360525

PRS4
26S proteasome regulatory subunit 4

2

5

High-throughput

0.521

High

360540

Q7JUS9
Phosphate carrier protein, mitochondrial

1

1

High-throughput

0.445

High

52633

A1Z729
NADP-retinol dehydrogenase

1

2

High-throughput

0.437

High

197134

RAB2
Ras-related protein Rab-2

1

1

High-throughput

0.437

High

360558

RAB5
Ras-related protein Rab5

1

1

High-throughput

0.437

High

360571

Q9VEV3
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.437

High

360591

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

360601

Q9VWL0
Mec2

1

4

High-throughput

0.437

High

360538

Q6IHY5
Cytochrome c oxidase subunit 7A-like 2, isoform A

1

0

High-throughput

0.426

High

55760

A1Z9K0
Uncharacterized protein, isoform B

1

1

High-throughput

0.407

High

58071

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

198015

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.407

High

360510

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

1

High-throughput

0.407

High

360511

MLR
Myosin regulatory light chain 2

1

1

High-throughput

0.407

High

360515

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.407

High

360519

SQH
Myosin regulatory light chain sqh

1

1

High-throughput

0.407

High

360530

ARL2
ADP-ribosylation factor-like protein 2

1

3

High-throughput

0.407

High

360531

ROP
Protein ROP

1

1

High-throughput

0.407

High

360532

Q0E931
GTP-binding protein 1

1

1

High-throughput

0.407

High

360542

Q7KMQ0
26S proteasome regulatory subunit 7

1

4

High-throughput

0.407

High

360543

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

2

High-throughput

0.407

High

360551

Q8SY39
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.407

High

360553

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

2

High-throughput

0.407

High

360554

LDH
L-lactate dehydrogenase

1

1

High-throughput

0.407

High

360556

Q95WY3
Nucleolar protein 56

1

1

High-throughput

0.407

High

360557

Q960C7
NADP-retinol dehydrogenase

1

2

High-throughput

0.407

High

360559

Q9V3V6
26S proteasome regulatory complex subunit p50

1

4

High-throughput

0.407

High

360560

Q9V405
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.407

High

360567

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

1

High-throughput

0.407

High

360573

ARL8
ADP-ribosylation factor-like protein 8

1

2

High-throughput

0.407

High

360576

DDX47
ATP-dependent RNA helicase DDX47

1

1

High-throughput

0.407

High

360580

Q9VKC8
FI03495p

1

1

High-throughput

0.407

High

360581

NFS1
Cysteine desulfurase, mitochondrial

1

1

High-throughput

0.407

High

360582

Q9VKU1
long-chain-fatty-acid--CoA ligase

1

1

High-throughput

0.407

High

360585

Q9VM69
Nucleolar protein 58

1

1

High-throughput

0.407

High

360590

Q9VS57
RE14391p

1

1

High-throughput

0.407

High

360592

Q9VSA9
CG7409

1

1

High-throughput

0.407

High

360607

RENT1
Regulator of nonsense transcripts 1 homolog

1

1

High-throughput

0.407

High

360608

Q9VZ88
AT07585p

1

1

High-throughput

0.407

High

360616

Q9W414
Regulatory particle triple-A ATPase 4

1

4

High-throughput

0.407

High

360619

SYQ
Probable glutamine--tRNA ligase

1

1

High-throughput

0.407

High

304179

ERD2
ER lumen protein-retaining receptor

2

0

High-throughput

0.298

High

360544

Q7KN94
Electron transfer flavoprotein subunit alpha

2

0

High-throughput

0.298

High

360564

Q9V9Q4
LD43819p

2

0

High-throughput

0.298

High

360572

IPO9
Importin-9

2

0

High-throughput

0.298

High

360613

Q9W335
Translocon-associated protein subunit alpha

2

0

High-throughput

0.298

High

197037

O18332
FI01544p

1

0

High-throughput

0.249

Low

360514

DDX6
ATP-dependent RNA helicase me31b

1

0

High-throughput

0.249

Low

360587

Q9VPR1
GH02075p

1

0

High-throughput

0.249

Low

360588

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

0

High-throughput

0.249

Low

53105

A1Z7K8
AaRS-interacting multifunctional protein 1

1

0

High-throughput

0.232

Low

55404

A1Z9E3
Elongation factor Tu

1

0

High-throughput

0.232

Low

263359

PENG
Protein penguin

1

0

High-throughput

0.232

Low

358443

ADH
Alcohol dehydrogenase

1

0

High-throughput

0.232

Low

360507

MLC1
Myosin light chain alkali

1

0

High-throughput

0.232

Low

360509

TPM2
Tropomyosin-2

1

0

High-throughput

0.232

Low

360512

TNNT
Troponin T, skeletal muscle

1

0

High-throughput

0.232

Low

360516

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

360517

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

0

High-throughput

0.232

Low

360518

TNNI
Troponin I

1

0

High-throughput

0.232

Low

360520

ARF4
ADP ribosylation factor 4

1

0

High-throughput

0.232

Low

360521

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.232

Low

360522

COPB
Coatomer subunit beta

1

0

High-throughput

0.232

Low

360523

ACTZ
Actin-related protein 1

1

0

High-throughput

0.232

Low

360524

TNNC1
Troponin C, isoform 1

1

0

High-throughput

0.232

Low

360526

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low

360527

KARG
Arginine kinase 1

1

0

High-throughput

0.232

Low

360528

PFKA
ATP-dependent 6-phosphofructokinase

1

0

High-throughput

0.232

Low

360529

DHE3
Glutamate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

360533

Q0E9E2
Pyruvate carboxylase

1

0

High-throughput

0.232

Low

360534

Q0KIB3
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.232

Low

360535

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

0

High-throughput

0.232

Low

360536

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.232

Low

360537

SARM1
NAD(+) hydrolase sarm1

1

0

High-throughput

0.232

Low

360539

Q6NP72
GEO09659p1

1

0

High-throughput

0.232

Low

360541

Q7JXU4
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low

360545

DYM
Dymeclin

1

0

High-throughput

0.232

Low

360546

CCD1D
Probable cytochrome P450 12d1 distal, mitochondrial

1

0

High-throughput

0.232

Low

360547

Q8I062
GH23305p

1

0

High-throughput

0.232

Low

360548

Q8IQB4
Z band alternatively spliced PDZ-motif protein 66, isoform E

1

0

High-throughput

0.232

Low

360549

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

360550

Q8STG9
DSec61alpha

1

0

High-throughput

0.232

Low

360552

Q8SY53
GH11935p

1

0

High-throughput

0.232

Low

360555

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

360561

API5
Apoptosis inhibitor 5 homolog

1

0

High-throughput

0.232

Low

360562

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

360563

Q9V455
Importin subunit alpha

1

0

High-throughput

0.232

Low

360565

Q9VAH7
N-terminal kinase-like protein

1

0

High-throughput

0.232

Low

360566

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

0

High-throughput

0.232

Low

360568

Q9VDK7
Signal recognition particle subunit SRP72

1

0

High-throughput

0.232

Low

360569

Q9VEH0
Aluminum tubes, isoform A

1

0

High-throughput

0.232

Low

360570

Q9VEP0
Regulatory protein zeste

1

0

High-throughput

0.232

Low

360574

Q9VI53
LD44267p

1

0

High-throughput

0.232

Low

360575

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

360578

Q9VJD1
Glucosidase 2 subunit beta

1

0

High-throughput

0.232

Low

360579

Q9VK46
Protein YIPF

1

0

High-throughput

0.232

Low

360583

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.232

Low

360584

Q9VM57
Septin interacting protein 2, isoform A

1

0

High-throughput

0.232

Low

360586

GMDS
GDP-mannose 4,6 dehydratase

1

0

High-throughput

0.232

Low

360589

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.232

Low

360593

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

360594

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.232

Low

360595

FRL
Formin-like protein

1

0

High-throughput

0.232

Low

360596

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.232

Low

360597

Q9VV51
1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform A

1

0

High-throughput

0.232

Low

360599

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.232

Low

360600

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low

360602

Q9VXG0
Cell division cycle 50, isoform A

1

0

High-throughput

0.232

Low

360603

Q9VXK5
Putative rRNA methyltransferase

1

0

High-throughput

0.232

Low

360604

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

360605

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

0

High-throughput

0.232

Low

360606

Q9VXR5
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.232

Low

360609

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

360610

Q9W0E4
Aminopeptidase

1

0

High-throughput

0.232

Low

360611

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

360612

Q9W1H8
acetyl-CoA C-acyltransferase

1

0

High-throughput

0.232

Low

360614

Q9W3N1
RH59310p

1

0

High-throughput

0.232

Low

360615

CISY
Probable citrate synthase, mitochondrial

1

0

High-throughput

0.232

Low

360617

Q9W4N8
LD30122p

1

0

High-throughput

0.232

Low

360618

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025