HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: NUP50 (Q9UKX7)
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
Gene: NUP50

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	24927568, 29568061, 34079125, 32344865, 22412018, unassigned1655
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 468
+	Hs
		595468 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		NUP50_HUMAN (1-468): 1.01e-131: 390: 100.00
+	Dr
		71514 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		Q6P0F8_DANRE (1-466): 1.91e-91: 285: 50.00
+	Hs
		360329 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RGPD5_HUMAN (196-468): 4.34e-39: 153: 14.34
+	Hs
		359736 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		359763 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Hs
		595127 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		595145 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60