HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22412018
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005200 - structural constituent of cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 639
+	Hs
		280786 KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		531551 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		359480 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		360200 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SH3R2_HUMAN (3-571): 1.68e-40: 159: 17.82
+	Hs
		359835 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924679 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924470 KRT85_HUMAN (25-387): 4.71e-48: 178: 24.93		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924895 KRT82_HUMAN (23-387): 1.44e-44: 168: 23.84		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924575 K1H2_HUMAN (30-387): 6.02e-43: 162: 23.18		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924741 KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		275169 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		443451 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		535366 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Ce
		953871 IFA1_CAEEL (18-547): 1.28e-45: 173: 27.31		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		443601 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		924469 KRT83_HUMAN (250-560): 7.81e-11: 66.8: 13.08		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924576 KRT81_HUMAN (250-556): 3.72e-10: 64.8: 12.93		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		535403 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		569085 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		422187 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64