Protein: COX2
Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II)

Gene: COX2, MT-CO2
Organism: Homo sapiens
Interactions: 159
UniProt ID: P00403

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004129 - cytochrome-c oxidase activity
GO:0005507 - copper ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360368

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

High-throughput

0.847

High

360239

COX1
Cytochrome c oxidase subunit 1

1

1

Small-scale

0.618

High

348299

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.616

High

360492

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

3

0

Small-scale

0.606

High

360363

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.586

High

360429

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

0

Small-scale

0.586

High

240422

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

360354

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

360358

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

360485

NLGN3
Neuroligin-3

1

0

Small-scale

0.568

High

360480

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

360418

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.546

High

360374

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

360355

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

360366

RALB
Ras-related protein Ral-B

2

2

High-throughput

0.521

High

360402

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.518

High

360367

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.513

High

360371

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.513

High

360377

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

360388

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

360415

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

360474

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.513

High

360395

NRAM2
Natural resistance-associated macrophage protein 2

1

0

Small-scale

0.506

High

360467

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.494

High

360406

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

360447

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.481

High

360398

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

1

High-throughput

0.481

High

228780

SCO2
Protein SCO2 homolog, mitochondrial

1

2

Small-scale

0.479

High

360380

STOM
Stomatin

1

5

High-throughput

0.479

High

360386

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

360389

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

360391

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

360409

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

360420

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

360422

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

360443

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

360446

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

360448

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

360450

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

360453

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

360458

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

360459

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

Small-scale

0.479

High

360472

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

360473

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

360478

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

360483

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

360486

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

360424

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

238334

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.460

High

360390

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

123305

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

292052

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

350760

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

360356

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

360359

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

360365

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

360372

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

360381

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

360384

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.458

High

360408

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

360410

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

360413

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

360417

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

360421

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.458

High

360430

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

Small-scale

0.458

High

360434

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.458

High

360435

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

360439

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

360444

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.458

High

360452

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

360454

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

360456

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

360461

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

360462

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

360464

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

360468

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

360477

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

360482

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

360484

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

360487

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

0

Small-scale

0.458

High

339630

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.457

High

360465

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

360364

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

360375

USF1
Upstream stimulatory factor 1

1

3

High-throughput

0.445

High

360449

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

360489

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

193482

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

Small-scale

0.437

High

208450

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

318557

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

323069

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.437

High

360360

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

360394

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

360405

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.437

High

360407

VIGLN
Vigilin

1

2

High-throughput

0.437

High

360425

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.437

High

360426

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.437

High

360437

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

360466

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

360470

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.437

High

360471

RHBT2
Rho-related BTB domain-containing protein 2

1

2

High-throughput

0.437

High

360475

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

360494

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.437

High

360369

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

360376

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

360412

CUL3
Cullin-3

1

0

High-throughput

0.426

High

360432

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

360445

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.426

High

360362

ELNE
Neutrophil elastase

1

1

Small-scale

0.417

High

360451

HTRA1
Serine protease HTRA1

1

1

Small-scale

0.417

High

360373

TFEB
Transcription factor EB

1

1

High-throughput

0.407

High

360383

RXRB
Retinoic acid receptor RXR-beta

1

2

High-throughput

0.407

High

360393

HD
Huntingtin

1

1

High-throughput

0.407

High

360399

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

360404

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

360491

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.407

High

360401

RHOA
Transforming protein RhoA

2

0

High-throughput

0.298

High

360357

FINC
Fibronectin

1

0

High-throughput

0.279

Low

360385

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.279

Low

360455

FAF2
FAS-associated factor 2

1

0

High-throughput

0.279

Low

360460

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.279

Low

360481

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

360379

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.251

Low

360396

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

360479

ECT2
Protein ECT2

1

0

High-throughput

0.251

Low

105050

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

125125

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

222620

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

259275

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

293006

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

360370

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

360378

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.249

Low

360382

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

360387

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

360392

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

360397

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

360400

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

360403

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

360411

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

360414

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

360416

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

360419

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

360423

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

360427

MIDN
Midnolin

1

0

High-throughput

0.249

Low

360428

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

360431

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

360433

ZN746
Zinc finger protein 746

1

0

High-throughput

0.249

Low

360436

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

360440

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

360441

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.249

Low

360442

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

360457

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

360463

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.249

Low

360469

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

360476

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.249

Low

360488

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

360493

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

360361

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

360438

S35D2
Nucleotide sugar transporter SLC35D2

1

0

High-throughput

0.232

Low

360490

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025