Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CD59 (P13987)
CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)
Gene: CD59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 39499777, 12577067
Identification Methods proximity labelling technology, fluorescent resonance energy transfer
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000139 - Golgi membrane
GO:0005615 - extracellular space
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 3 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 128
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025