Protein: CD59
CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)

Gene: CD59
Organism: Homo sapiens
Interactions: 95
UniProt ID: P13987

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001848 - complement binding
GO:0001971 - negative regulation of activation of membrane attack complex
GO:0005615 - extracellular space
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

569214

TINAL
Tubulointerstitial nephritis antigen-like

3

0

High-throughput

0.638

High

563110

CFTR
Cystic fibrosis transmembrane conductance regulator

3

0

High-throughput

0.616

High

388816

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

2

1

Small-scale

0.602

High

569199

TM11B
Transmembrane protease serine 11B

2

0

High-throughput

0.602

High

362686

EGFR
Epidermal growth factor receptor

2

1

High-throughput

0.595

High

569162

CD27
CD27 antigen

2

0

High-throughput

0.585

High

569195

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

395417

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

569211

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

569169

CCR2
C-C chemokine receptor type 2

1

1

High-throughput

0.541

High

569164

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

569219

PARVG
Gamma-parvin

1

1

High-throughput

0.536

High

466863

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.518

High

292534

RENR
Renin receptor

1

0

High-throughput

0.513

High

297048

DHRS3
Short-chain dehydrogenase/reductase 3

1

0

High-throughput

0.513

High

473648

ITA5
Integrin alpha-5

1

0

High-throughput

0.513

High

476424

IBP1
Insulin-like growth factor-binding protein 1

1

0

High-throughput

0.513

High

569160

FLNA
Filamin-A

1

0

High-throughput

0.513

High

569161

PRPH2
Peripherin-2

1

0

High-throughput

0.513

High

569166

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

569172

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.513

High

569177

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

569190

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

569191

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

569201

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

569210

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

569220

KC1G1
Casein kinase I isoform gamma-1

1

0

High-throughput

0.513

High

569230

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

456935

CO8A
Complement component C8 alpha chain

1

1

Small-scale

0.501

High

369222

ISK1
Serine protease inhibitor Kazal-type 1

1

0

High-throughput

0.493

High

569189

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

Small-scale

0.493

High

569200

PIM3
Serine/threonine-protein kinase pim-3

1

1

High-throughput

0.489

High

378900

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

0

Small-scale

0.480

High

410571

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

569180

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

569186

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

569212

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.460

High

168371

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

Small-scale

0.458

High

217775

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

302016

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

Small-scale

0.458

High

370147

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

548400

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

569163

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

569165

BASI
Basigin

1

0

High-throughput

0.458

High

569167

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

569168

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

569171

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

569176

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

569184

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

569188

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

569216

SIK2
Serine/threonine-protein kinase SIK2

1

0

Small-scale

0.458

High

569217

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

323145

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.437

High

330623

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

569175

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.437

High

569205

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.437

High

569206

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

569213

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.437

High

569215

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

569226

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.437

High

569229

RNF6
E3 ubiquitin-protein ligase RNF6

1

1

High-throughput

0.437

High

538509

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.426

High

569196

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

569197

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.426

High

569203

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.426

High

569209

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

569221

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

High-throughput

0.426

High

569225

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.426

High

569179

GALK2
N-acetylgalactosamine kinase

2

0

High-throughput

0.328

High

569174

UBE2A
Ubiquitin-conjugating enzyme E2 A

2

0

High-throughput

0.318

High

569170

HD
Huntingtin

2

0

High-throughput

0.306

High

569181

DUS4
Dual specificity protein phosphatase 4

2

0

High-throughput

0.298

High

569192

DREB
Drebrin

1

0

High-throughput

0.279

Low

569202

TBCK
TBC domain-containing protein kinase-like protein

1

0

High-throughput

0.279

Low

569204

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

569207

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.279

Low

569208

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

569183

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.265

Low

247644

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

371056

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

569159

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

569173

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

569178

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

569185

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

569187

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

569193

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low

569194

MIDN
Midnolin

1

0

High-throughput

0.249

Low

569198

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

569218

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

569222

ANLN
Anillin

1

0

High-throughput

0.249

Low

569223

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

569224

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.249

Low

569227

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

569228

SEPT9
Septin-9

1

0

Small-scale

0.249

Low

569182

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025