HitPredict - High confidence protein-protein interactions

Interactor 1: FINC (P02751)
Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Gene: FN1

Interactor 2: TSP1 (P07996)
Thrombospondin-1 (Glycoprotein G)
Gene: THBS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	19542224, 18226512, 18042364
Identification Methods	pull down, solid phase assay, surface plasmon resonance array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF_3~fn3
Common GO terms	GO:0002020 - protease binding GO:0005178 - integrin binding GO:0005201 - extracellular matrix structural constituent GO:0005576 - extracellular region GO:0005577 - fibrinogen complex and 12 others more... GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0007155 - cell adhesion GO:0008201 - heparin binding GO:0008284 - positive regulation of cell population proliferation GO:0018149 - peptide cross-linking GO:0031012 - extracellular matrix GO:0031093 - platelet alpha granule lumen GO:0043394 - proteoglycan binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0062023 - collagen-containing extracellular matrix GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	2477
Hs

1	1170

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024