Protein: ERBB4
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]

Gene: ERBB4
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q15303

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0001755 - neural crest cell migration
GO:0001934 - positive regulation of protein phosphorylation
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410861

ERBB2
Receptor tyrosine-protein kinase erbB-2

9

19

Small-scale

0.965

High

363317

EGFR
Epidermal growth factor receptor

7

20

Small-scale

0.960

High

1145733

ERBB4
Receptor tyrosine-protein kinase erbB-4

5

20

Small-scale

0.930

High

711357

SHC1
SHC-transforming protein 1

5

20

Small-scale

0.916

High

1006068

DLG4
Disks large homolog 4

4

20

Small-scale

0.903

High

987656

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.884

High

1053668

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.872

High

1145766

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

20

Small-scale

0.871

High

641602

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

19

Small-scale

0.829

High

838365

STA5A
Signal transducer and activator of transcription 5A

3

20

Small-scale

0.827

High

711131

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

High-throughput

0.817

High

660071

COF1
Cofilin-1

3

5

High-throughput

0.814

High

1036205

NRG1
Pro-neuregulin-1, membrane-bound isoform

2

20

Small-scale

0.792

High

136389

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.789

High

362296

ABL1
Tyrosine-protein kinase ABL1

2

19

High-throughput

0.778

High

635720

RASA1
Ras GTPase-activating protein 1

2

20

High-throughput

0.778

High

840959

ABL2
Tyrosine-protein kinase ABL2

2

19

High-throughput

0.778

High

849177

KSYK
Tyrosine-protein kinase SYK

2

20

High-throughput

0.778

High

222085

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.768

High

594007

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.768

High

855631

CRK
Adapter molecule crk

2

20

Small-scale

0.768

High

1091498

DLG1
Disks large homolog 1

2

20

Small-scale

0.754

High

461499

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.743

High

986852

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

2

9

High-throughput

0.743

High

1145768

LRRC7
Leucine-rich repeat-containing protein 7

2

20

High-throughput

0.743

High

1145737

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.724

High

1145744

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

20

Small-scale

0.724

High

862152

YAP1
Transcriptional coactivator YAP1

5

20

Small-scale

0.720

High

440567

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.713

High

1145790

WWOX
WW domain-containing oxidoreductase

5

2

Small-scale

0.704

High

155415

PTPRT
Receptor-type tyrosine-protein phosphatase T

1

20

High-throughput

0.698

High

767051

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

20

High-throughput

0.698

High

1050795

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.698

High

1144523

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

1145765

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.667

High

468395

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

1104825

SNTB2
Beta-2-syntrophin

1

20

Small-scale

0.656

High

1145735

DLG2
Disks large homolog 2

1

20

Small-scale

0.656

High

1145761

DLG3
Disks large homolog 3

1

20

Small-scale

0.656

High

1145791

HDAC6
Protein deacetylase HDAC6

3

8

Small-scale

0.653

High

1145738

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

20

Small-scale

0.648

High

154427

SH2B2
SH2B adapter protein 2

1

20

High-throughput

0.647

High

155112

SOCS2
Suppressor of cytokine signaling 2

1

20

High-throughput

0.647

High

155946

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.647

High

156042

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.647

High

164861

SH21B
SH2 domain-containing protein 1B

1

20

High-throughput

0.647

High

187353

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

12

High-throughput

0.647

High

193278

SOCS1
Suppressor of cytokine signaling 1

1

20

High-throughput

0.647

High

258601

SH21A
SH2 domain-containing protein 1A

1

20

High-throughput

0.647

High

273310

SOCS5
Suppressor of cytokine signaling 5

1

20

High-throughput

0.647

High

292835

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.647

High

294862

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.647

High

440083

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.647

High

456108

FES
Tyrosine-protein kinase Fes/Fps

1

20

High-throughput

0.647

High

463099

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.647

High

463527

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.647

High

473422

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.647

High

486696

FGR
Tyrosine-protein kinase Fgr

1

20

High-throughput

0.647

High

557317

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.647

High

584544

VAV
Proto-oncogene vav

1

20

High-throughput

0.647

High

599291

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

19

High-throughput

0.647

High

619062

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

19

High-throughput

0.647

High

699758

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.647

High

840852

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

20

High-throughput

0.647

High

840883

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

840912

TXK
Tyrosine-protein kinase TXK

1

20

High-throughput

0.647

High

849068

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.647

High

902839

BLK
Tyrosine-protein kinase Blk

1

20

High-throughput

0.647

High

913652

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.647

High

1004308

3BP2
SH3 domain-binding protein 2

1

16

High-throughput

0.647

High

1022106

SHC2
SHC-transforming protein 2

1

20

High-throughput

0.647

High

1065082

ITK
Tyrosine-protein kinase ITK/TSK

1

20

High-throughput

0.647

High

1094302

LCP2
Lymphocyte cytosolic protein 2

1

20

High-throughput

0.647

High

1098885

SLAP1
Src-like-adapter

1

20

High-throughput

0.647

High

1102326

GRB10
Growth factor receptor-bound protein 10

1

20

High-throughput

0.647

High

1118405

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.647

High

1126610

GRB7
Growth factor receptor-bound protein 7

1

20

High-throughput

0.647

High

1145734

SHB
SH2 domain-containing adapter protein B

1

20

High-throughput

0.647

High

1145741

TENS2
Tensin-2

1

20

High-throughput

0.647

High

1145742

TENS3
Tensin-3

1

20

High-throughput

0.647

High

1145743

SHC4
SHC-transforming protein 4

1

20

High-throughput

0.647

High

1145746

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

20

High-throughput

0.647

High

1145748

TENS4
Tensin-4

1

20

High-throughput

0.647

High

1145751

SH2D3
SH2 domain-containing protein 3C

1

20

High-throughput

0.647

High

1145757

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.647

High

1145758

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.647

High

1145759

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

20

High-throughput

0.647

High

1145767

HSH2D
Hematopoietic SH2 domain-containing protein

1

20

High-throughput

0.647

High

1145780

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.647

High

1145785

SH22A
SH2 domain-containing protein 2A

1

20

High-throughput

0.647

High

1145787

SH2B1
SH2B adapter protein 1

1

20

High-throughput

0.647

High

1145793

VAV3
Guanine nucleotide exchange factor VAV3

1

20

High-throughput

0.647

High

1145794

STAP1
Signal-transducing adaptor protein 1

1

5

High-throughput

0.647

High

1145795

SH2B3
SH2B adapter protein 3

1

20

High-throughput

0.647

High

861615

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.634

High

1145777

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

20

Small-scale

0.634

High

1086532

TROP
Trophinin

2

5

Small-scale

0.624

High

1145740

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

20

High-throughput

0.621

High

238818

KALRN
Kalirin

1

17

Small-scale

0.618

High

710252

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

730601

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

855876

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

907274

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.618

High

971552

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.618

High

155143

NRG2
Pro-neuregulin-2, membrane-bound isoform

2

11

Small-scale

0.602

High

1145778

RNF41
E3 ubiquitin-protein ligase NRDP1

2

12

Small-scale

0.595

High

1145773

LRRC1
Leucine-rich repeat-containing protein 1

1

20

Small-scale

0.590

High

1145784

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

20

High-throughput

0.590

High

1145764

SHD
SH2 domain-containing adapter protein D

1

20

High-throughput

0.579

High

1145782

TENS1
Tensin-1

1

20

High-throughput

0.579

High

402602

ALDOA
Fructose-bisphosphate aldolase A

2

5

High-throughput

0.576

High

528260

THIO
Thioredoxin

2

16

High-throughput

0.576

High

716433

PRDX5
Peroxiredoxin-5, mitochondrial

2

2

High-throughput

0.576

High

952178

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

6

High-throughput

0.576

High

1145745

I2BP2
Interferon regulatory factor 2-binding protein 2

2

17

High-throughput

0.576

High

1145750

SIM20
Small integral membrane protein 20

2

2

High-throughput

0.576

High

1145775

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

2

3

High-throughput

0.576

High

1145781

TM134
Transmembrane protein 134

2

2

High-throughput

0.576

High

1145783

ZN532
Zinc finger protein 532

2

4

High-throughput

0.576

High

1145786

RTN4
Reticulon-4

2

5

High-throughput

0.576

High

1145797

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

2

4

High-throughput

0.576

High

1145799

SELK
Selenoprotein K

2

2

High-throughput

0.576

High

1145800

TM14A
Transmembrane protein 14A

2

1

High-throughput

0.576

High

1118863

BYST
Bystin

1

0

Small-scale

0.561

High

1145760

AP2C
Transcription factor AP-2 gamma

1

2

Small-scale

0.561

High

1145788

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

13

Small-scale

0.552

High

58725

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

20

High-throughput

0.541

High

290934

PPM1B
Protein phosphatase 1B

1

10

High-throughput

0.541

High

719329

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.541

High

776959

PPM1A
Protein phosphatase 1A

1

10

High-throughput

0.541

High

884826

PPM1F
Protein phosphatase 1F

1

20

High-throughput

0.541

High

1112404

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

15

High-throughput

0.541

High

1145736

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

11

High-throughput

0.541

High

1145739

DUS6
Dual specificity protein phosphatase 6

1

20

High-throughput

0.541

High

1145753

DUS18
Dual specificity protein phosphatase 18

1

20

High-throughput

0.541

High

1145755

DUS19
Dual specificity protein phosphatase 19

1

20

High-throughput

0.541

High

1145756

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.541

High

1145769

MTMR9
Myotubularin-related protein 9

1

15

High-throughput

0.541

High

1145774

DUS16
Dual specificity protein phosphatase 16

1

20

High-throughput

0.541

High

1145776

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

High-throughput

0.541

High

1145779

DUS21
Dual specificity protein phosphatase 21

1

20

High-throughput

0.541

High

1145796

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

15

High-throughput

0.541

High

1145801

DUS10
Dual specificity protein phosphatase 10

1

20

High-throughput

0.541

High

686814

S10A4
Protein S100-A4

1

15

Small-scale

0.536

High

176350

SYNEM
Synemin

2

16

High-throughput

0.526

High

252766

AP180
Clathrin coat assembly protein AP180

2

16

High-throughput

0.526

High

1145762

TM230
Transmembrane protein 230

2

2

High-throughput

0.526

High

1145763

F241B
Protein FAM241B

2

2

High-throughput

0.526

High

1145789

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

3

High-throughput

0.526

High

1145792

ERG28
Ergosterol biosynthetic protein 28 homolog

2

2

High-throughput

0.526

High

1145798

TMA7
Translation machinery-associated protein 7

2

2

High-throughput

0.526

High

278351

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.515

High

962955

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.515

High

1145770

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.513

High

326705

DUS14
Dual specificity protein phosphatase 14

1

20

High-throughput

0.494

High

731770

S10AB
Protein S100-A11

1

15

High-throughput

0.481

High

1145772

MUC4
Mucin-4

1

19

Small-scale

0.481

High

168923

EREG
Proepiregulin [Cleaved into: Epiregulin

1

2

Small-scale

0.479

High

172840

XPO1
Exportin-1

1

19

Small-scale

0.479

High

174514

TRI66
Tripartite motif-containing protein 66

1

11

High-throughput

0.479

High

396158

ESR1
Estrogen receptor

1

14

Small-scale

0.479

High

413879

P53
Cellular tumor antigen p53

1

10

Small-scale

0.479

High

431569

AP2A
Transcription factor AP-2-alpha

1

2

Small-scale

0.479

High

590283

MUC1
Mucin-1

1

18

Small-scale

0.479

High

591300

CD44
CD44 antigen

1

5

Small-scale

0.479

High

603988

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

651335

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

828212

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

13

Small-scale

0.479

High

1028209

MDM2
E3 ubiquitin-protein ligase Mdm2

1

8

Small-scale

0.479

High

1051666

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

10

Small-scale

0.479

High

1099919

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.479

High

1114835

CUL4A
Cullin-4A

1

14

High-throughput

0.479

High

1145747

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

Small-scale

0.479

High

1145749

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.479

High

1145754

VANG1
Vang-like protein 1

1

4

Small-scale

0.479

High

1145771

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

1

19

Small-scale

0.479

High

1145802

PIAS3
E3 SUMO-protein ligase PIAS3

1

1

Small-scale

0.479

High

408892

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

5

High-throughput

0.457

High

954956

S10AA
Protein S100-A10

1

15

High-throughput

0.457

High

292350

RA51D
DNA repair protein RAD51 homolog 4

1

3

High-throughput

0.445

High

333014

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

14

High-throughput

0.445

High

641954

CD9
CD9 antigen

1

8

High-throughput

0.445

High

1145752

GOLM1
Golgi membrane protein 1

1

1

Small-scale

0.445

High

1086498

TROAP
Tastin

1

0

Small-scale

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025