HitPredict

Interactor 1: TFR1 (P02786)
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Gene: TFRC

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.73 0.60 0.662

The method score is based on:

Property Details
Experiments 26496610, 35384245, 24189400
Identification Methods affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0010008 - endosome membrane
GO:0016020 - membrane
and 4 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 760
Hs

1 1255
+ Hs
+ Hs
+ Hs
+ Rn
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024