Protein: M3K13
Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)

Gene: M3K13, MAP3K13
Organism: Homo sapiens
Interactions: 44
UniProt ID: O43283

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

187228

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

2

9

High-throughput

0.726

High

212012

STAT3
Signal transducer and activator of transcription 3

1

5

High-throughput

0.698

High

212016

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

212017

CSK21
Casein kinase II subunit alpha

1

20

High-throughput

0.691

High

212026

FLNC
Filamin-C

1

7

High-throughput

0.691

High

167770

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.665

High

212002

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

19

Small-scale

0.665

High

161903

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

Small-scale

0.647

High

212010

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

2

4

Small-scale

0.644

High

212040

KLH20
Kelch-like protein 20

2

3

High-throughput

0.628

High

212039

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

15

Small-scale

0.618

High

212028

H2A2C
Histone H2A type 2-C

2

2

High-throughput

0.574

High

212025

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.561

High

212029

LRC47
Leucine-rich repeat-containing protein 47

1

4

Small-scale

0.553

High

212018

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

2

High-throughput

0.541

High

212004

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

212008

TBG1
Tubulin gamma-1 chain

1

9

High-throughput

0.536

High

212021

TP53B
TP53-binding protein 1

1

2

High-throughput

0.536

High

212024

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.536

High

212032

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.536

High

212033

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

5

High-throughput

0.536

High

212034

ZFR
Zinc finger RNA-binding protein

1

1

High-throughput

0.536

High

212035

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

212037

SMC4
Structural maintenance of chromosomes protein 4

1

7

High-throughput

0.536

High

212020

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.518

High

212006

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.513

High

212023

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

212030

GT251
Procollagen galactosyltransferase 1

1

0

High-throughput

0.513

High

212038

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

212007

SON
Protein SON

1

3

High-throughput

0.489

High

212027

AINX
Alpha-internexin

1

10

High-throughput

0.489

High

212003

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

212005

MYH3
Myosin-3

1

14

High-throughput

0.479

High

212009

TKT
Transketolase

1

2

Small-scale

0.479

High

212011

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

212014

RAGP1
Ran GTPase-activating protein 1

1

3

Small-scale

0.479

High

212015

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.479

High

212036

GNL3
Guanine nucleotide-binding protein-like 3

1

1

Small-scale

0.479

High

212022

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

212031

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.437

High

212013

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

212019

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.279

Low

212041

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025