HitPredict

Interactor 1: TFR1 (P02786)
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Gene: TFRC

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0033138 - positive regulation of peptidyl-serine phosphorylation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 760 Hs			1 839
+	Hs
		364129 TFR1_HUMAN (1-760): 0: 971: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		364152 TFR1_HUMAN (1-760): 0: 971: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		364294 TFR1_HUMAN (1-760): 0: 971: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		364255 TFR1_HUMAN (1-760): 0: 971: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		364141 TFR1_HUMAN (1-760): 0: 971: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		544919 TFR1_RAT (1-760): 0: 939: 76.25		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Rn
		70289 TFR2_RAT (54-760): 0: 723: 42.67		INSR_RAT (513-824): 3.31e-62: 230: 38.80