HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: HRK1 (Q08732)
Serine/threonine-protein kinase HRK1 (EC 2.7.11.1) (Hygromycin resistance kinase 1)
Gene: HRK1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26804907
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Sc			1 759
+	Hs
		437928 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT2_HUMAN (92-558): 4.1e-131: 399: 14.59
+	Mm
		513660 HS90B_MOUSE (5-709): 0: 1029: 61.68		AKT1_MOUSE (92-540): 6.04e-129: 394: 14.91
+	Bt
		964601 HS90B_BOVIN (5-709): 0: 1026: 62.13		AKT1_BOVIN (92-540): 3.69e-129: 394: 14.69
+	Hs
		437927 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT1_HUMAN (92-540): 1.52e-128: 393: 14.91
+	Hs
		431573 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT2_HUMAN (92-558): 4.1e-131: 399: 14.59
+	Hs
		438633 HS90B_HUMAN (5-709): 0: 1026: 62.13		AKT3_HUMAN (103-526): 1.02e-125: 385: 16.28
+	Hs
		431572 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT1_HUMAN (92-540): 1.52e-128: 393: 14.91
+	Rn
		812703 HS90A_RAT (4-709): 0: 1014: 60.72		AKT1_RAT (92-540): 8.33e-129: 393: 15.35
+	Mm
		432411 HS90A_MOUSE (4-709): 0: 1012: 60.72		AKT1_MOUSE (92-540): 6.04e-129: 394: 14.91
+	Hs
		432376 HS90A_HUMAN (4-709): 0: 1015: 60.83		AKT3_HUMAN (103-526): 1.02e-125: 385: 16.28
+	Hs
		437908 HS90B_HUMAN (5-709): 0: 1026: 62.13		CDK2_HUMAN (211-510): 2.26e-119: 362: 23.95
+	Hs
		431549 HS90A_HUMAN (4-709): 0: 1015: 60.83		CDK2_HUMAN (211-510): 2.26e-119: 362: 23.95
+	Hs
		438075 HS90B_HUMAN (5-709): 0: 1026: 62.13		CDK3_HUMAN (211-504): 3.91e-111: 341: 23.93
+	Hs
		431741 HS90A_HUMAN (4-709): 0: 1015: 60.83		CDK3_HUMAN (211-504): 3.91e-111: 341: 23.93
+	Sc
		367057 HSP82_YEAST (1-709): 0: 984: 100.00		RTK1_YEAST (183-445): 1.27e-75: 258: 54.98
+	Sc
		544573 HSC82_YEAST (1-709): 0: 973: 94.64		RTK1_YEAST (183-445): 1.27e-75: 258: 54.98
+	Sc
		543212 HSC82_YEAST (1-709): 0: 973: 94.64		NPR1_YEAST (83-441): 3.63e-69: 244: 44.21
+	Hs
		154118 HS90B_HUMAN (5-709): 0: 1026: 62.13		CHK1_HUMAN (217-427): 9.85e-20: 95.1: 31.31
+	Hs
		154117 HS90A_HUMAN (4-709): 0: 1015: 60.83		CHK1_HUMAN (217-427): 9.85e-20: 95.1: 31.31
+	Sc
		543730 HSC82_YEAST (1-709): 0: 973: 94.64		HAL5_YEAST (198-459): 2.48e-30: 130: 31.31