HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	11266503, 31527615, 33731348, unassigned1953
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016020 - membrane GO:0032991 - protein-containing complex and 1 others more... GO:0071889 - 14-3-3 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 245
+	Hs
		369315 ESR1_HUMAN (1-595): 0: 599: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		369354 ESR1_HUMAN (1-595): 0: 599: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		369070 ESR1_HUMAN (1-595): 0: 599: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		369071 ESR1_HUMAN (1-595): 0: 599: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		369308 ESR1_HUMAN (1-595): 0: 599: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		909878 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		647162 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		927369 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683595 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		320172 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Mm
		509305 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	Hs
		684247 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904942 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		683175 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Mm
		509343 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Hs
		377131 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		377266 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		437636 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Mm
		509296 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		1433G_MOUSE (1-242): 5.48e-105: 305: 70.33
+	Hs
		740490 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33