Protein: ASSY
Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)

Gene: ASSY, ASS1
Organism: Homo sapiens
Interactions: 129
UniProt ID: P00966

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0000052 - citrulline metabolic process
GO:0000053 - argininosuccinate metabolic process
GO:0001822 - kidney development
GO:0001889 - liver development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368998

ASSY
Argininosuccinate synthase

3

3

High-throughput

0.862

High

368999

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.656

High

369011

PYC
Pyruvate carboxylase, mitochondrial

2

0

High-throughput

0.602

High

369063

Z354C
Zinc finger protein 354C

2

0

High-throughput

0.602

High

369099

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

2

0

High-throughput

0.602

High

369100

ANM7
Protein arginine N-methyltransferase 7

1

1

Small-scale

0.586

High

240435

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

369034

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

369052

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.552

High

369109

NGN3
Neurogenin-3

2

1

High-throughput

0.549

High

358568

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.536

High

369017

USF1
Upstream stimulatory factor 1

1

3

High-throughput

0.536

High

369027

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

369043

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.536

High

369073

NGN1
Neurogenin-1

1

1

High-throughput

0.536

High

253264

JAK2
Tyrosine-protein kinase JAK2

1

0

High-throughput

0.518

High

369015

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.518

High

369088

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

64787

EPAB2
Embryonic polyadenylate-binding protein 2

1

0

High-throughput

0.513

High

221495

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.513

High

279606

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.513

High

369001

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.513

High

369003

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

369007

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

369009

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.513

High

369010

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

369020

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.513

High

369036

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

369037

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

369042

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

369065

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.513

High

369079

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.513

High

369080

SORT
Sortilin

1

0

High-throughput

0.513

High

369082

GDF15
Growth/differentiation factor 15

1

0

High-throughput

0.513

High

369087

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.513

High

369092

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.513

High

369098

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

369104

OAZ3
Ornithine decarboxylase antizyme 3

1

0

High-throughput

0.513

High

369093

NMRL1
NmrA-like family domain-containing protein 1

1

0

Small-scale

0.493

High

369012

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

369006

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.486

High

369026

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

369004

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

369038

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

259278

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

342085

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

369002

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

369033

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.479

High

369039

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

369041

1433F
14-3-3 protein eta

1

2

High-throughput

0.479

High

369051

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

369060

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

369061

ASB18
Ankyrin repeat and SOCS box protein 18

1

1

High-throughput

0.479

High

369076

ASB9
Ankyrin repeat and SOCS box protein 9

1

1

High-throughput

0.479

High

369081

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.479

High

369102

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

369111

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

369000

MT2
Metallothionein-2

1

0

High-throughput

0.460

High

369044

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

348921

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

354486

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.458

High

369008

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

369014

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

369018

SP100
Nuclear autoantigen Sp-100

1

0

High-throughput

0.458

High

369019

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

369024

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

369028

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

369029

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

369031

COPD
Coatomer subunit delta

1

0

High-throughput

0.458

High

369032

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.458

High

369035

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

369046

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

369047

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

369055

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

369056

FTM
Protein fantom

1

0

High-throughput

0.458

High

369057

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

369062

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

369066

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

369071

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

369074

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

369075

OPTN
Optineurin

1

0

High-throughput

0.458

High

369078

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.458

High

369083

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

369086

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

369094

ANLN
Anillin

1

0

High-throughput

0.458

High

369096

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

369103

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.458

High

369105

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

369108

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.458

High

369023

1433S
14-3-3 protein sigma

1

2

High-throughput

0.445

High

369040

CDR2
Cerebellar degeneration-related protein 2

1

0

Small-scale

0.438

High

369053

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

369005

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

369085

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

369095

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

369106

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

369097

CAH10
Carbonic anhydrase-related protein 10

4

0

High-throughput

0.360

High

369059

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

369090

AKTIP
AKT-interacting protein

1

0

High-throughput

0.282

High

328216

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

329197

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

369013

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.279

Low

369016

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

369021

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

369022

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.279

Low

369025

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.279

Low

369030

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

369048

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.279

Low

369058

F117B
Protein FAM117B

1

0

High-throughput

0.279

Low

369067

LGI2
Leucine-rich repeat LGI family member 2

1

0

High-throughput

0.279

Low

369068

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.279

Low

369077

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

369089

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

369091

SFXN1
Sideroflexin-1

1

0

High-throughput

0.279

Low

369101

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

369110

MPC1
Mitochondrial pyruvate carrier 1

1

0

High-throughput

0.279

Low

369084

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

239648

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

369049

ZN846
Zinc finger protein 846

1

0

High-throughput

0.249

Low

369050

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

369054

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

369064

DOPP1
Dolichyldiphosphatase 1

1

0

High-throughput

0.249

Low

369069

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

369070

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

369072

PHIP
PH-interacting protein

1

0

High-throughput

0.249

Low

369107

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

260823

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.232

Low

369045

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025